Seroatlas · Human Serome Atlas

FKBP15

FK506-binding protein 15

Also known as: FKB15_HUMAN, FKBP133, KIAA0674, PPP1R76, WAFL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T1M5
Gene: FKBP15
Ensembl: ENSG00000119321
Chromosome: 9
Canonical length: 1219 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable actin binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in endocytosis. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1219 residues, UniProt reviewed canonical sequence.

>Q5T1M5|FKBP15
     1  MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG QGTAATGNQA
    61  TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV LGNHTAREYR ILLYISQQQP
   121  VTVARIHVNF ELMVRPNNYS TFYDDQRQNW SIMFESEKAA VEFNKQVCIA KCNSTSSLDA
   181  VLSQDLIVAD GPAVEVGDSL EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG
   241  WEDGMLGMKK GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH
   301  SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ LAINTSPDAV
   361  KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG QPVVTPSVQP SLHPAHPALP
   421  QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH SAVSGNAQSF QPYAGMQAYA YPQASAVTSQ
   481  LQPVRPLYPA PLSQPPHFQG SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL
   541  QKHSAGNSML IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSNRIEE QNDKISELIE
   601  RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA QVSHLQLKMT
   661  AHQKKETELQ MQLTESLKET DLLRGQLTKV QAKLSELQET SEQAQSKFKS EKQNRKQLEL
   721  KVTSLEEELT DLRVEKESLE KNLSERKKKS AQERSQAEEE IDEIRKSYQE ELDKLRQLLK
   781  KTRVSTDQAA AEQLSLVQAE LQTQWEAKCE HLLASAKDEH LQQYQEVCAQ RDAYQQKLVQ
   841  LQEKCLALQA QITALTKQNE QHIKELEKNK SQMSGVEAAA SDPSEKVKKI MNQVFQSLRR
   901  EFELEESYNG RTILGTIMNT IKMVTLQLLN QQEQEKEESS SEEEEEKAEE RPRRPSQEQS
   961  ASASSGQPQA PLNRERPESP MVPSEQVVEE AVPLPPQALT TSQDGHRRKG DSEAEALSEI
  1021  KDGSLPPELS CIPSHRVLGP PTSIPPEPLG PVSMDSECEE SLAASPMAAK PDNPSGKVCV
  1081  REVAPDGPLQ ESSTRLSLTS DPEEGDPLAL GPESPGEPQP PQLKKDDVTS STGPHKELSS
  1141  TEAGSTVAGA ALRPSHHSQR SSLSGDEEDE LFKGATLKAL RPKAQPEEED EDEVSMKGRP
  1201  PPTPLFGDDD DDDDIDWLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 11 nTPM
spleen: 8.6 nTPM
appendix: 6.8 nTPM
bone marrow: 6.5 nTPM
skin: 5.8 nTPM
lymph node: 5.5 nTPM

Single-cell type

neutrophils: 178 nCPM
kupffer cells: 137 nCPM
microglia: 124 nCPM
monocytes: 122 nCPM
macrophages: 120 nCPM
hofbauer cells: 109 nCPM

Immune cell

non-classical monocyte: 5 nTPM
neutrophil: 3.4 nTPM
classical monocyte: 1.7 nTPM
intermediate monocyte: 1.7 nTPM
naive B-cell: 1.2 nTPM
myeloid DC: 1.1 nTPM

Brain region

white matter: 28 nTPM
medulla oblongata: 22 nTPM
basal ganglia: 20 nTPM
thalamus: 18 nTPM
pons: 18 nTPM
cerebral cortex: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 1.58
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

endocytosis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

FKBP-type peptidyl-prolyl cis-trans isomerase domain
Peptidyl-prolyl cis-trans isomerase domain superfamily
FKBP-type peptidyl-prolyl cis-trans isomerase
FK506-binding protein 15-like domain
FK506-binding protein 15-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBP15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP15 as an antibody target. Whether an autoantibody or antibody against FKBP15 could matter depends on whether native FKBP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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