Seroatlas · Human Serome Atlas

VPS26B

Vacuolar protein sorting-associated protein 26B

Also known as: MGC10485, Pep8b, VP26B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4G0F5
Gene
VPS26B
Ensembl
ENSG00000151502
Chromosome
11
Canonical length
336 aa
Protein class
Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in early endosome and late endosome. Predicted to be part of retromer complex. Predicted to be active in glutamatergic synapse; postsynaptic early endosome; and postsynaptic recycling endosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q4G0F5|VPS26B
     1  MSFFGFGQSV EVEILLNDAE SRKRAEHKTE DGKKEKYFLF YDGETVSGKV SLALKNPNKR
    61  LEHQGIKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIT QSQAFDFEFT HVEKPYESYT
   121  GQNVKLRYFL RATISRRLND VVKEMDIVVH TLSTYPELNS SIKMEVGIED CLHIEFEYNK
   181  SKYHLKDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR
   241  GESIPIRLFL AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR
   301  KSMSHQAAIA SQRFEGTTSL GEVRTPSQLS DNNCRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS26B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 44 nTPM
  • cerebellum: 44 nTPM
  • basal ganglia: 38 nTPM
  • hippocampal formation: 34 nTPM
  • skin: 33 nTPM
  • amygdala: 32 nTPM

Single-cell type

  • late spermatids: 110 nCPM
  • megakaryocytes: 99 nCPM
  • cardiomyocytes: 82 nCPM
  • neutrophil progenitors: 79 nCPM
  • oocytes: 69 nCPM
  • enterocytes: 64 nCPM

Immune cell

  • eosinophil: 8.3 nTPM
  • memory CD8 T-cell: 5.8 nTPM
  • NK-cell: 5.5 nTPM
  • gdT-cell: 5.4 nTPM
  • naive CD8 T-cell: 5.3 nTPM
  • T-reg: 5.2 nTPM

Brain region

  • hippocampal formation: 64 nTPM
  • cerebral cortex: 63 nTPM
  • basal ganglia: 60 nTPM
  • hypothalamus: 52 nTPM
  • amygdala: 52 nTPM
  • thalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
2.02
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS26B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS26B as an antibody target. Whether an autoantibody or antibody against VPS26B could matter depends on whether native VPS26B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS26B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS26B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS26B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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