Seroatlas · Human Serome Atlas

SNX17

Sorting nexin-17

Also known as: KIAA0064, SNX17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15036
Gene
SNX17
Ensembl
ENSG00000115234
Chromosome
2
Canonical length
470 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q15036|SNX17
     1  MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE YGANVLPAFP
    61  PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS FLRRAQQETQ QVPTEEVSLE
   121  VLLSNGQKVL VNVLTSDQTE DVLEAVAAKL DLPDDLIGYF SLFLVREKED GAFSFVRKLQ
   181  EFELPYVSVT SLRSQEYKIV LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIERGWILVT
   241  KEQHRQLKSL QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ
   301  LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGSTSSPGRG RGEVRLELAF EYLMSKDRLQ
   361  WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV GGTLRRSDSQ QAVKSPPLLE
   421  SPDATRESMV KLSSKLSAVS LRGIGSPSTD ASASDVHGNF AFEGIGDEDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 43 nTPM
  • adrenal gland: 43 nTPM
  • pancreas: 42 nTPM
  • heart muscle: 41 nTPM
  • thymus: 41 nTPM
  • parathyroid gland: 40 nTPM

Single-cell type

  • cytotrophoblasts: 205 nCPM
  • migrating cytotrophoblasts: 170 nCPM
  • extravillous trophoblasts: 162 nCPM
  • megakaryocytes: 155 nCPM
  • esophageal apical cells: 141 nCPM
  • decidual stromal cells: 133 nCPM

Immune cell

  • total PBMC: 231 nTPM
  • non-classical monocyte: 147 nTPM
  • classical monocyte: 139 nTPM
  • myeloid DC: 136 nTPM
  • intermediate monocyte: 135 nTPM
  • eosinophil: 89 nTPM

Brain region

  • pons: 47 nTPM
  • spinal cord: 46 nTPM
  • white matter: 46 nTPM
  • cerebellum: 43 nTPM
  • thalamus: 42 nTPM
  • medulla oblongata: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX17 as an antibody target. Whether an autoantibody or antibody against SNX17 could matter depends on whether native SNX17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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