Seroatlas · Human Serome Atlas

CCDC93

Coiled-coil domain-containing protein 93

Also known as: CCD93_HUMAN, FLJ10996

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q567U6
Gene: CCDC93
Ensembl: ENSG00000125633
Chromosome: 2
Canonical length: 631 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Involved in Golgi to plasma membrane transport and endocytic recycling. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>Q567U6|CCDC93
     1  MGLPRGPEGQ GLPEVETRED EEQNVKLTEI LELLVAAGYF RARIKGLSPF DKVVGGMTWC
    61  ITTCNFDVDV DLLFQENSTI GQKIALSEKI VSVLPRMKCP HQLEPHQIQG MDFIHIFPVV
   121  QWLVKRAIET KEEMGDYIRS YSVSQFQKTY SLPEDDDFIK RKEKAIKTVV DLSEVYKPRR
   181  KYKRHQGAEE LLDEESRIHA TLLEYGRRYG FSRQSKMEKA EDKKTALPAG LSATEKADAH
   241  EEDELRAAEE QRIQSLMTKM TAMANEESRL TASSVGQIVG LCSAEIKQIV SEYAEKQSEL
   301  SAEESPEKLG TSQLHRRKVI SLNKQIAQKT KHLEELRASH TSLQARYNEA KKTLTELKTY
   361  SEKLDKEQAA LEKIESKADP SILQNLRALV AMNENLKSQE QEFKAHCREE MTRLQQEIEN
   421  LKAERAPRGD EKTLSSGEPP GTLTSAMTHD EDLDRRYNME KEKLYKIRLL QARRNREIAI
   481  LHRKIDEVPS RAELIQYQKR FIELYRQISA VHKETKQFFT LYNTLDDKKV YLEKEISLLN
   541  SIHENFSQAM ASPAARDQFL RQMEQIVEGI KQSRMKMEKK KQENKMRRDQ LNDQYLELLE
   601  KQRLYFKTVK EFKEEGRKNE MLLSKVKAKA S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC93 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

retina: 24 nTPM
bone marrow: 21 nTPM
heart muscle: 20 nTPM
cerebellum: 16 nTPM
pituitary gland: 16 nTPM
parathyroid gland: 15 nTPM

Single-cell type

neutrophils: 258 nCPM
adrenal cortex cells: 218 nCPM
choroid plexus epithelial cells: 139 nCPM
corticotrophs: 120 nCPM
neutrophil progenitors: 119 nCPM
distal convoluted tubule cells: 108 nCPM

Immune cell

basophil: 2.9 nTPM
gdT-cell: 2.1 nTPM
intermediate monocyte: 2.1 nTPM
MAIT T-cell: 2 nTPM
naive CD4 T-cell: 2 nTPM
eosinophil: 1.8 nTPM

Brain region

choroid plexus: 29 nTPM
cerebral cortex: 25 nTPM
thalamus: 22 nTPM
pons: 19 nTPM
hypothalamus: 18 nTPM
medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 1.08
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

early endosome

Protein domainsUniProt · Pfam · InterPro

CCDC93, coiled-coil domain
Coiled-coil domain-containing protein 93
CCDC93, N-terminal domain
CCDC93 coiled-coil domain
CCDC93 protein N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC93 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC93 as an antibody target. Whether an autoantibody or antibody against CCDC93 could matter depends on whether native CCDC93 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC93 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC93 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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