Seroatlas · Human Serome Atlas

WASHC2C

WASH complex subunit 2C

Also known as: Em:AC012044.3, FAM21C, KIAA0592, WAC2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y4E1
Gene
WASHC2C
Ensembl
ENSG00000172661
Chromosome
10
Canonical length
1341 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoli,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol phosphate binding activity and retromer complex binding activity. Involved in protein localization to endosome. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1341 residues, UniProt reviewed canonical sequence.

>Q9Y4E1|WASHC2C
     1  MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE
    61  IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK
   121  TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI
   181  DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN
   241  EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD
   301  AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL
   361  FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG
   421  AASVPSLKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA
   481  DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD
   541  EEDSEDLFSS QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE
   601  EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT LQSQEAKAVK
   661  KTSLFEEDKE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS LFGSPPTSVP PATKKKETVS
   721  EAPPLLFSDE EEKEAQLGVK SVDKKVESAK ESLKFGRTDV AESEKEGLLT RSAQETVKHS
   781  DLFSSSSPWD KGTKPRTKTV LSLFDEEEDK MEDQNIIQAP QKEVGKGCDP DAHPKSTGVF
   841  QDEELLFSHK LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK
   901  KRVVKKDHSV NSFKNQKHPE SIQGSKEKGI WKPETPQDSS GLAPFKTKEP STRIGKIQAN
   961  LAINPAALLP TAASQISEVK PVLPELAFPS SEHRRSHGLE SVPVLPGSGE AGVSFDLPAQ
  1021  ADTLHSANKS RVKMRGKRRP QTRAARRLAA QESSEAEDMS VPRGPIAQWA DGAISPNGHR
  1081  PQLRAASGED STEEALAAAA APWEGGPVPG VDTSPFAKSL GHSRGEADLF DSGDIFSTGT
  1141  GSQSVERTKP KAKIAENPAN PPVGGKAKSP MFPALGEASS DDDLFQSAKP KPAKKTNPFP
  1201  LLEDEDDLFT DQKVKKNETK SSSQQDVILT TQDIFEDDIF ATEAIKPSQK TREKEKTLES
  1261  NLFDDNIDIF ADLTVKPKEK SKKKVEAKSI FDDDMDDIFS TGIQAKTTKP KSRSAQAAPE
  1321  PRFEHKVSNI FDDPLNAFGG Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WASHC2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 40 nTPM
  • rectum: 21 nTPM
  • heart muscle: 21 nTPM
  • parathyroid gland: 20 nTPM
  • cerebellum: 20 nTPM
  • thymus: 20 nTPM

Single-cell type

  • neutrophils: 96 nCPM
  • monocytes: 66 nCPM
  • neutrophil progenitors: 62 nCPM
  • monocyte progenitors: 57 nCPM
  • macrophages: 55 nCPM
  • kupffer cells: 52 nCPM

Immune cell

  • non-classical monocyte: 23 nTPM
  • intermediate monocyte: 18 nTPM
  • classical monocyte: 17 nTPM
  • neutrophil: 17 nTPM
  • basophil: 14 nTPM
  • total PBMC: 13 nTPM

Brain region

  • cerebral cortex: 29 nTPM
  • cerebellum: 28 nTPM
  • thalamus: 28 nTPM
  • choroid plexus: 26 nTPM
  • white matter: 25 nTPM
  • pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
DepMap mean gene effect
-0.49
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WASHC2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WASHC2C as an antibody target. Whether an autoantibody or antibody against WASHC2C could matter depends on whether native WASHC2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WASHC2C is annotated at the cell surface, where native WASHC2C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label WASHC2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WASHC2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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