Seroatlas · Human Serome Atlas

SNX3

Sorting nexin-3

Also known as: Grd19, SNX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60493
Gene: SNX3
Ensembl: ENSG00000112335
Chromosome: 6
Canonical length: 162 aa
Protein class: Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

162 residues, UniProt reviewed canonical sequence.

>O60493|SNX3
     1  MAETVADTRR LITKPQNLND AYGPPSNFLE IDVSNPQTVG VGRGRFTTYE IRVKTNLPIF
    61  KLKESTVRRR YSDFEWLRSE LERESKVVVP PLPGKAFLRQ LPFRGDDGIF DDNFIEERKQ
   121  GLEQFINKVA GHPLAQNERC LHMFLQDEII DKSYTPSKIR HA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 303 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 303 nTPM
bone marrow: 280 nTPM
tongue: 267 nTPM
heart muscle: 250 nTPM
cerebral cortex: 228 nTPM
amygdala: 223 nTPM

Single-cell type

esophageal apical cells: 1,675 nCPM
hofbauer cells: 1,602 nCPM
esophageal suprabasal cells: 942 nCPM
megakaryocytes: 859 nCPM
cytotrophoblasts: 794 nCPM
late spermatids: 787 nCPM

Immune cell

memory B-cell: 216 nTPM
naive B-cell: 183 nTPM
eosinophil: 170 nTPM
plasmacytoid DC: 132 nTPM
basophil: 119 nTPM
myeloid DC: 110 nTPM

Brain region

cerebral cortex: 185 nTPM
white matter: 167 nTPM
hippocampal formation: 149 nTPM
spinal cord: 143 nTPM
hypothalamus: 142 nTPM
midbrain: 142 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.25
gnomAD missense Z: 1.73
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX3 as an antibody target. Whether an autoantibody or antibody against SNX3 could matter depends on whether native SNX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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