RGS2
Regulator of G-protein signaling 2
Also known as: G0S8, RGS2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P41220
- Gene
- RGS2
- Ensembl
- ENSG00000116741
- Chromosome
- 1
- Canonical length
- 211 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]
Canonical amino-acid sequenceUniProt
211 residues, UniProt reviewed canonical sequence.
>P41220|RGS2
1 MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT
61 GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK
121 KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL
181 MENNSYPRFL ESEFYQDLCK KPQITTEPHA TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RGS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 534 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 534 nTPM
- pancreas: 484 nTPM
- smooth muscle: 473 nTPM
- adrenal gland: 334 nTPM
- colon: 311 nTPM
- urinary bladder: 296 nTPM
Single-cell type
- neutrophils: 2,605 nCPM
- mast cells: 1,540 nCPM
- breast secretory cells: 748 nCPM
- monocytes: 696 nCPM
- cdc: 607 nCPM
- smooth muscle cells: 603 nCPM
Immune cell
- neutrophil: 4,391 nTPM
- basophil: 3,275 nTPM
- eosinophil: 757 nTPM
- classical monocyte: 519 nTPM
- non-classical monocyte: 365 nTPM
- total PBMC: 310 nTPM
Brain region
- choroid plexus: 66 nTPM
- cerebral cortex: 63 nTPM
- medulla oblongata: 51 nTPM
- hypothalamus: 46 nTPM
- pons: 40 nTPM
- midbrain: 36 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.42
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.01
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- brown fat cell differentiation
- G protein-coupled receptor signaling pathway
- maternal process involved in female pregnancy
- negative regulation of cardiac muscle hypertrophy
- negative regulation of cell growth involved in cardiac muscle cell development
- negative regulation of G protein-coupled receptor signaling pathway
- negative regulation of glycine import across plasma membrane
- negative regulation of JNK cascade
- negative regulation of translation
- positive regulation of cardiac muscle contraction
- positive regulation of neuron projection development
- positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
- regulation of G protein-coupled receptor signaling pathway
- relaxation of cardiac muscle
- relaxation of vascular associated smooth muscle
- response to amphetamine
- response to ethanol
- spermatogenesis
- regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway
Molecular functions
- adenylate cyclase inhibitor activity
- beta-tubulin binding
- calmodulin binding
- G-protein alpha-subunit binding
- GTPase activator activity
- GTPase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- RGS domain
- RGS, subdomain 1/3
- RGS domain superfamily
- RGS, subdomain 2
- Regulator of G protein signaling domain
- Regulator of G-protein signalling 2, regulator of G protein signaling domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RGS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RGS2 as an antibody target. Whether an autoantibody or antibody against RGS2 could matter depends on whether native RGS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RGS2 is annotated at the cell surface, where native RGS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RGS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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