Seroatlas · Human Serome Atlas

COMMD6

COMM domain-containing protein 6

Also known as: Acrg, COMD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4G1
Gene: COMMD6
Ensembl: ENSG00000188243
Chromosome: 13
Canonical length: 85 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>Q7Z4G1|COMMD6
     1  MEASSEPPLD AKSDVTNQLV DFQWKLGMAV SSDTCRSLKY PYVAVMLKVA DHSGQVKTKC
    61  FEMTIPQFQN FYRQFKEIAA VIETV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 205 nTPM

Expression across tissuesHPA

Tissue

ovary: 205 nTPM
lymph node: 160 nTPM
adrenal gland: 157 nTPM
epididymis: 156 nTPM
thyroid gland: 136 nTPM
bone marrow: 126 nTPM

Single-cell type

parietal cells: 1,734 nCPM
decidual stromal cells: 1,073 nCPM
ovarian stromal cells: 907 nCPM
epididymal principal cells: 838 nCPM
breast myoepithelial cells: 799 nCPM
esophageal suprabasal cells: 785 nCPM

Immune cell

plasmacytoid DC: 1000 nTPM
memory B-cell: 688 nTPM
T-reg: 658 nTPM
naive CD4 T-cell: 641 nTPM
naive B-cell: 600 nTPM
total PBMC: 584 nTPM

Brain region

white matter: 39 nTPM
spinal cord: 38 nTPM
choroid plexus: 34 nTPM
hypothalamus: 33 nTPM
cerebellum: 32 nTPM
medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.17
gnomAD missense Z: -0.69
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

NF-kappaB binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD6 as an antibody target. Whether an autoantibody or antibody against COMMD6 could matter depends on whether native COMMD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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