Seroatlas · Human Serome Atlas

CTNNB1

Catenin beta-1

Also known as: armadillo, beta-catenin, CTNB1_HUMAN, CTNNB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35222
Gene
CTNNB1
Ensembl
ENSG00000168036
Chromosome
3
Canonical length
781 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions,Primary cilium,Basal body

OverviewNCBI Gene

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

781 residues, UniProt reviewed canonical sequence.

>P35222|CTNNB1
     1  MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS
    61  QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT
   121  NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK
   181  KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL
   241  VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC
   301  LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA
   361  GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA
   421  AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM
   481  AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL
   541  VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV
   601  QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF
   661  RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH
   721  SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD
   781  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTNNB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
188 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 188 nTPM
  • breast: 182 nTPM
  • ovary: 179 nTPM
  • blood vessel: 173 nTPM
  • cervix: 169 nTPM
  • smooth muscle: 167 nTPM

Single-cell type

  • monocytes: 872 nCPM
  • syncytiotrophoblasts: 763 nCPM
  • transitional alveolar cells: 638 nCPM
  • pituicytes/fscs: 633 nCPM
  • alveolar cells type 2: 592 nCPM
  • innate lymphoid cells: 541 nCPM

Immune cell

  • non-classical monocyte: 13 nTPM
  • intermediate monocyte: 12 nTPM
  • myeloid DC: 12 nTPM
  • MAIT T-cell: 11 nTPM
  • T-reg: 11 nTPM
  • memory CD8 T-cell: 10 nTPM

Brain region

  • cerebellum: 315 nTPM
  • thalamus: 279 nTPM
  • midbrain: 249 nTPM
  • amygdala: 231 nTPM
  • spinal cord: 230 nTPM
  • hypothalamus: 229 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTNNB1.

Disease | AllUniProt

Conditions CTNNB1 is implicated in, by any mechanism.

Disease | GeneticClinVar

242 pathogenic / likely-pathogenic of 968 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Severe intellectual disability-progressive spastic diplegia syndrome
  • Inborn genetic diseases
  • CTNNB1-related disorder
  • Adamantinous craniopharyngioma
  • Pilomatrixoma

Disease | ImmuneIEDB

Conditions an epitope on CTNNB1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
3.85
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTNNB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTNNB1 as an antibody target. Whether an autoantibody or antibody against CTNNB1 could matter depends on whether native CTNNB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTNNB1 is annotated at the cell surface, where native CTNNB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CTNNB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTNNB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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