Seroatlas · Human Serome Atlas

TTI1

TELO2-interacting protein 1 homolog

Also known as: KIAA0406, smg-10, TTI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43156
Gene: TTI1
Ensembl: ENSG00000101407
Chromosome: 20
Canonical length: 1089 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Involved in positive regulation of DNA damage checkpoint and regulation of TOR signaling. Located in cytoplasm. Part of TORC1 complex; TORC2 complex; and TTT Hsp90 cochaperone complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1089 residues, UniProt reviewed canonical sequence.

>O43156|TTI1
     1  MAVFDTPEEA FGVLRPVCVQ LTKTQTVENV EHLQTRLQAV SDSALQELQQ YILFPLRFTL
    61  KTPGPKRERL IQSVVECLTF VLSSTCVKEQ ELLQELFSEL SACLYSPSSQ KPAAVSEELK
   121  LAVIQGLSTL MHSAYGDIIL TFYEPSILPR LGFAVSLLLG LAEQEKSKQI KIAALKCLQV
   181  LLLQCDCQDH PRSLDELEQK QLGDLFASFL PGISTALTRL ITGDFKQGHS IVVSSLKIFY
   241  KTVSFIMADE QLKRISKVQA KPAVEHRVAE LMVYREADWV KKTGDKLTIL IKKIIECVSV
   301  HPHWKVRLEL VELVEDLLLK CSQSLVECAG PLLKALVGLV NDESPEIQAQ CNKVLRHFAD
   361  QKVVVGNKAL ADILSESLHS LATSLPRLMN SQDDQGKFST LSLLLGYLKL LGPKINFVLN
   421  SVAHLQRLSK ALIQVLELDV ADIKIVEERR WNSDDLNASP KTSATQPWNR IQRRYFRFFT
   481  DERIFMLLRQ VCQLLGYYGN LYLLVDHFME LYHQSVVYRK QAAMILNELV TGAAGLEVED
   541  LHEKHIKTNP EELREIVTSI LEEYTSQENW YLVTCLETEE MGEELMMEHP GLQAITSGEH
   601  TCQVTSFLAF SKPSPTICSM NSNIWQICIQ LEGIGQFAYA LGKDFCLLLM SALYPVLEKA
   661  GDQTLLISQV ATSTMMDVCR ACGYDSLQHL INQNSDYLVN GISLNLRHLA LHPHTPKVLE
   721  VMLRNSDANL LPLVADVVQD VLATLDQFYD KRAASFVSVL HALMAALAQW FPDTGNLGHL
   781  QEQSLGEEGS HLNQRPAALE KSTTTAEDIE QFLLNYLKEK DVADGNVSDF DNEEEEQSVP
   841  PKVDENDTRP DVEPPLPLQI QIAMDVMERC IHLLSDKNLQ IRLKVLDVLD LCVVVLQSHK
   901  NQLLPLAHQA WPSLVHRLTR DAPLAVLRAF KVLRTLGSKC GDFLRSRFCK DVLPKLAGSL
   961  VTQAPISARA GPVYSHTLAF KLQLAVLQGL GPLCERLDLG EGDLNKVADA CLIYLSVKQP
  1021  VKLQEAARSV FLHLMKVDPD STWFLLNELY CPVQFTPPHP SLHPVQLHGA SGQQNPYTTN
  1081  VLQLLKELQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 15 nTPM
pancreas: 13 nTPM
thymus: 13 nTPM
tonsil: 12 nTPM
thyroid gland: 11 nTPM
liver: 11 nTPM

Single-cell type

mast cells: 75 nCPM
pancreatic acinar cells: 72 nCPM
thyrotrophs: 55 nCPM
myonuclei: 47 nCPM
erythrocyte progenitors: 45 nCPM
adrenal cortex cells: 42 nCPM

Immune cell

eosinophil: 15 nTPM
basophil: 14 nTPM
myeloid DC: 11 nTPM
MAIT T-cell: 11 nTPM
naive CD4 T-cell: 11 nTPM
T-reg: 9.9 nTPM

Brain region

white matter: 23 nTPM
choroid plexus: 19 nTPM
cerebral cortex: 19 nTPM
hypothalamus: 19 nTPM
thalamus: 18 nTPM
medulla oblongata: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TTI1.

Disease | AllUniProt

Conditions TTI1 is implicated in, by any mechanism.

Neurodevelopmental disorder with microcephaly and movement abnormalities (NEDMIM) MIM:620445

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 247 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with microcephaly and movement abnormalities
Severe intellectual disability
Abnormal brain morphology
Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.81
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
TEL2-interacting protein 1
TELO2-interacting protein 1, middle region repeats
TELO2-interacting protein 1 homolog
TTI1, N-terminal TPR domain
TTI1, C-terminal TPR domain
TELO2-interacting protein 1
TTI1 N-terminal TPR domain
TELO2-interacting protein 1 homologue second TPR domain
TTI1 C-terminal TPR domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTI1 as an antibody target. Whether an autoantibody or antibody against TTI1 could matter depends on whether native TTI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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