Seroatlas · Human Serome Atlas

ECD

Protein ecdysoneless homolog

Also known as: ECD_HUMAN, GCR2, hSGT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95905
Gene: ECD
Ensembl: ENSG00000122882
Chromosome: 10
Canonical length: 644 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables histone acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

644 residues, UniProt reviewed canonical sequence.

>O95905|ECD
     1  MEETMKLATM EDTVEYCLFL IPDESRDSDK HKEILQKYIE RIITRFAPML VPYIWQNQPF
    61  NLKYKPGKGG VPAHMFGVTK FGDNIEDEWF IVYVIKQITK EFPELVARIE DNDGEFLLIE
   121  AADFLPKWLD PENSTNRVFF CHGELCIIPA PRKSGAESWL PTTPPTIPQA LNIITAHSEK
   181  ILASESIRAA VNRRIRGYPE KIQASLHRAH CFLPAGIVAV LKQRPRLVAA AVQAFYLRDP
   241  IDLRACRVFK TFLPETRIMT SVTFTKCLYA QLVQQRFVPD RRSGYRLPPP SDPQYRAHEL
   301  GMKLAHGFEI LCSKCSPHFS DCKKSLVTAS PLWASFLESL KKNDYFKGLI EGSAQYRERL
   361  EMAENYFQLS VDWPESSLAM SPGEEILTLL QTIPFDIEDL KKEAANLPPE DDDQWLDLSP
   421  DQLDQLLQEA VGKKESESVS KEEKEQNYDL TEVSESMKAF ISKVSTHKGA ELPREPSEAP
   481  ITFDADSFLN YFDKILGPRP NESDSDDLDD EDFECLDSDD DLDFETHEPG EEASLKGTLD
   541  NLKSYMAQMD QELAHTCISK SFTTRNQVEP VSQTTDNNSD EEDSGTGESV MAPVDVDLNL
   601  VSNILESYSS QAGLAGPASN LLQSMGVQLP DNTDHRPTSK PTKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ECD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
parathyroid gland: 21 nTPM
thymus: 20 nTPM
urinary bladder: 19 nTPM
testis: 18 nTPM
thyroid gland: 18 nTPM

Single-cell type

neutrophils: 125 nCPM
epididymal principal cells: 83 nCPM
neutrophil progenitors: 81 nCPM
endometrial glandular cells: 78 nCPM
urothelial cells: 75 nCPM
cardiomyocytes: 74 nCPM

Immune cell

non-classical monocyte: 35 nTPM
NK-cell: 33 nTPM
naive CD4 T-cell: 30 nTPM
neutrophil: 28 nTPM
MAIT T-cell: 27 nTPM
eosinophil: 26 nTPM

Brain region

cerebellum: 40 nTPM
white matter: 38 nTPM
basal ganglia: 36 nTPM
choroid plexus: 35 nTPM
cerebral cortex: 34 nTPM
hippocampal formation: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: -2.01
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

histone acetyltransferase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ecd family
SGT1 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ECD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ECD as an antibody target. Whether an autoantibody or antibody against ECD could matter depends on whether native ECD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ECD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ECD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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