Seroatlas · Human Serome Atlas

PPP1R10

Serine/threonine-protein phosphatase 1 regulatory subunit 10

Also known as: CAT53, FB19, p99, PNUTS, PP1RA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96QC0
Gene
PPP1R10
Ensembl
ENSG00000204569
Chromosome
6
Canonical length
940 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

940 residues, UniProt reviewed canonical sequence.

>Q96QC0|PPP1R10
     1  MGSGPIDPKE LLKGLDSFLN RDGEVKSVDG ISKIFSLMKE ARKMVSRCTY LNILLQTRSP
    61  EILVKFIDVG GYKLLNNWLT YSKTTNNIPL LQQILLTLQH LPLTVDHLKQ NNTAKLVKQL
   121  SKSSEDEELR KLASVLVSDW MAVIRSQSST QPAEKDKKKR KDEGKSRTTL PERPLTEVKA
   181  ETRAEEAPEK KREKPKSLRT TAPSHAKFRS TGLELETPSL VPVKKNASTV VVSDKYNLKP
   241  IPLKRQSNVA APGDATPPAE KKYKPLNTTP NATKEIKVKI IPPQPMEGLG FLDALNSAPV
   301  PGIKIKKKKK VLSPTAAKPS PFEGKTSTEP STAKPSSPEP APPSEAMDAD RPGTPVPPVE
   361  VPELMDTASL EPGALDAKPV ESPGDPNQLT RKGRKRKSVT WPEEGKLREY FYFELDETER
   421  VNVNKIKDFG EAAKREILSD RHAFETARRL SHDNMEEKVP WVCPRPLVLP SPLVTPGSNS
   481  QERYIQAERE KGILQELFLN KESPHEPDPE PYEPIPPKLI PLDEECSMDE TPYVETLEPG
   541  GSGGSPDGAG GSKLPPVLAN LMGSMGAGKG PQGPGGGGIN VQEILTSIMG SPNSHPSEEL
   601  LKQPDYSDKI KQMLVPHGLL GPGPIANGFP PGGPGGPKGM QHFPPGPGGP MPGPHGGPGG
   661  PVGPRLLGPP PPPRGGDPFW DGPGDPMRGG PMRGGPGPGP GPYHRGRGGR GGNEPPPPPP
   721  PFRGARGGRS GGGPPNGRGG PGGGMVGGGG HRPHEGPGGG MGNSSGHRPH EGPGGGMGSG
   781  HRPHEGPGGS MGGGGGHRPH EGPGGGISGG SGHRPHEGPG GGMGAGGGHR PHEGPGGSMG
   841  GSGGHRPHEG PGHGGPHGHR PHDVPGHRGH DHRGPPPHEH RGHDGPGHGG GGHRGHDGGH
   901  SHGGDMSNRP VCRHFMMKGN CRYENNCAFY HPGVNGPPLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • liver: 32 nTPM
  • adrenal gland: 27 nTPM
  • pancreas: 27 nTPM
  • pituitary gland: 25 nTPM
  • urinary bladder: 25 nTPM
  • stomach: 24 nTPM

Single-cell type

  • epididymal basal cells: 149 nCPM
  • microglia: 111 nCPM
  • breast lactating cells: 89 nCPM
  • breast secretory cells: 76 nCPM
  • endometrial secretory cells: 76 nCPM
  • innate lymphoid cells: 71 nCPM

Immune cell

  • basophil: 7.8 nTPM
  • myeloid DC: 3.3 nTPM
  • memory B-cell: 2.7 nTPM
  • intermediate monocyte: 2.1 nTPM
  • eosinophil: 1.9 nTPM
  • memory CD8 T-cell: 1.8 nTPM

Brain region

  • cerebral cortex: 2.9 nTPM
  • midbrain: 2.6 nTPM
  • medulla oblongata: 2.5 nTPM
  • hippocampal formation: 1.1 nTPM
  • pons: 1.1 nTPM
  • hypothalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
2.95
DepMap mean gene effect
-1.23
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R10 as an antibody target. Whether an autoantibody or antibody against PPP1R10 could matter depends on whether native PPP1R10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP1R10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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