Seroatlas · Human Serome Atlas

TNPO1

Transportin-1

Also known as: IPO2, KPNB2, MIP, MIP1, TNPO1_HUMAN, TRN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92973
Gene
TNPO1
Ensembl
ENSG00000083312
Chromosome
5
Canonical length
898 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nucleoli,Cytosol,Cytoplasmic bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018]

Canonical amino-acid sequenceUniProt

898 residues, UniProt reviewed canonical sequence.

>Q92973|TNPO1
     1  MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ YPDFNNYLIF
    61  VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK SECLNNIGDS SPLIRATVGI
   121  LITTIASKGE LQNWPDLLPK LCSLLDSEDY NTCEGAFGAL QKICEDSAEI LDSDVLDRPL
   181  NIMIPKFLQF FKHSSPKIRS HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR
   241  KNVCRALVML LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV
   301  LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS RTVAQQHDED
   361  GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD ELLPHILPLL KELLFHHEWV
   421  VKESGILVLG AIAEGCMQGM IPYLPELIPH LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ
   481  PPDTYLKPLM TELLKRILDS NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK
   541  YQHKNLLILY DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS
   601  VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI VALDLLSGLA
   661  EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG DLTKACFQHV KPCIADFMPI
   721  LGTNLNPEFI SVCNNATWAI GEISIQMGIE MQPYIPMVLH QLVEIINRPN TPKTLLENTA
   781  ITIGRLGYVC PQEVAPMLQQ FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF
   841  IFFCDAVASW INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNPO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • retina: 75 nTPM
  • parathyroid gland: 44 nTPM
  • testis: 40 nTPM
  • thyroid gland: 40 nTPM
  • placenta: 38 nTPM
  • pancreas: 33 nTPM

Single-cell type

  • rod photoreceptor cells: 587 nCPM
  • myonuclei: 416 nCPM
  • neutrophil progenitors: 409 nCPM
  • pituitary stem cells: 345 nCPM
  • lactotrophs: 303 nCPM
  • neutrophils: 290 nCPM

Immune cell

  • MAIT T-cell: 17 nTPM
  • NK-cell: 14 nTPM
  • non-classical monocyte: 14 nTPM
  • gdT-cell: 12 nTPM
  • naive CD8 T-cell: 12 nTPM
  • naive CD4 T-cell: 12 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • white matter: 69 nTPM
  • hypothalamus: 65 nTPM
  • medulla oblongata: 64 nTPM
  • spinal cord: 58 nTPM
  • midbrain: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.06
gnomAD pLI
1
gnomAD missense Z
4.33
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNPO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNPO1 as an antibody target. Whether an autoantibody or antibody against TNPO1 could matter depends on whether native TNPO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNPO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNPO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNPO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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