Seroatlas · Human Serome Atlas

LUC7L3

Luc7-like protein 3

Also known as: CRA, CREAP-1, CROP, FLJ11063, hLuc7A, LC7L3_HUMAN, LUC7A, OA48-18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95232
Gene
LUC7L3
Ensembl
ENSG00000108848
Chromosome
17
Canonical length
432 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>O95232|LUC7L3
     1  MISAAQLLDE LMGRDRNLAP DEKRSNVRWD HESVCKYYLC GFCPAELFTN TRSDLGPCEK
    61  IHDENLRKQY EKSSRFMKVG YERDFLRYLQ SLLAEVERRI RRGHARLALS QNQQSSGAAG
   121  PTGKNEEKIQ VLTDKIDVLL QQIEELGSEG KVEEAQGMMK LVEQLKEERE LLRSTTSTIE
   181  SFAAQEKQME VCEVCGAFLI VGDAQSRVDD HLMGKQHMGY AKIKATVEEL KEKLRKRTEE
   241  PDRDERLKKE KQEREEREKE REREREERER KRRREEEERE KERARDRERR KRSRSRSRHS
   301  SRTSDRRCSR SRDHKRSRSR ERRRSRSRDR RRSRSHDRSE RKHRSRSRDR RRSKSRDRKS
   361  YKHRSKSRDR EQDRKSKEKE KRGSDDKKSS VKSGSREKQS EDTNTESKES DTKNEVNGTS
   421  EDIKSEGDTQ SN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LUC7L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
295 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 295 nTPM
  • ovary: 213 nTPM
  • cervix: 168 nTPM
  • retina: 163 nTPM
  • pituitary gland: 163 nTPM
  • fallopian tube: 158 nTPM

Single-cell type

  • sertoli cells: 824 nCPM
  • leydig cells: 674 nCPM
  • tuft cells: 542 nCPM
  • myonuclei: 488 nCPM
  • peritubular myoid cells: 478 nCPM
  • lactotrophs: 475 nCPM

Immune cell

  • memory B-cell: 68 nTPM
  • plasmacytoid DC: 65 nTPM
  • naive B-cell: 56 nTPM
  • basophil: 50 nTPM
  • neutrophil: 49 nTPM
  • naive CD4 T-cell: 38 nTPM

Brain region

  • cerebellum: 175 nTPM
  • white matter: 138 nTPM
  • hypothalamus: 119 nTPM
  • thalamus: 109 nTPM
  • cerebral cortex: 109 nTPM
  • basal ganglia: 109 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.09
gnomAD pLI
1
gnomAD missense Z
2.58
DepMap mean gene effect
-1.66
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LUC7L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LUC7L3 as an antibody target. Whether an autoantibody or antibody against LUC7L3 could matter depends on whether native LUC7L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LUC7L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LUC7L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LUC7L3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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