Seroatlas · Human Serome Atlas

NUDT21

Cleavage and polyadenylation specificity factor subunit 5

Also known as: CFIM25, CPSF5, CPSF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43809
Gene
NUDT21
Ensembl
ENSG00000167005
Chromosome
16
Canonical length
227 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear bodies,Centriolar satellite
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>O43809|NUDT21
     1  MSVVPPNRSQ TGWPRGVTQF GNKYIQQTKP LTLERTINLY PLTNYTFGTK EPLYEKDSSV
    61  AARFQRMREE FDKIGMRRTV EGVLIVHEHR LPHVLLLQLG TTFFKLPGGE LNPGEDEVEG
   121  LKRLMTEILG RQDGVLQDWV IDDCIGNWWR PNFEPPQYPY IPAHITKPKE HKKLFLVQLQ
   181  EKALFAVPKN YKLVAAPLFE LYDNAPGYGP IISSLPQLLS RFNFIYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • testis: 66 nTPM
  • tonsil: 61 nTPM
  • bone marrow: 61 nTPM
  • thymus: 54 nTPM
  • lymph node: 53 nTPM
  • ovary: 49 nTPM

Single-cell type

  • gastric progenitor cells: 58 nCPM
  • parietal cells: 42 nCPM
  • brain inhibitory neurons: 41 nCPM
  • gastric chief cells: 38 nCPM
  • distal convoluted tubule cells: 38 nCPM
  • oligodendrocytes: 38 nCPM

Immune cell

  • T-reg: 46 nTPM
  • basophil: 30 nTPM
  • eosinophil: 30 nTPM
  • memory CD4 T-cell: 28 nTPM
  • non-classical monocyte: 27 nTPM
  • neutrophil: 26 nTPM

Brain region

  • hypothalamus: 74 nTPM
  • cerebral cortex: 65 nTPM
  • cerebellum: 61 nTPM
  • basal ganglia: 61 nTPM
  • white matter: 61 nTPM
  • pons: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
3.47
DepMap mean gene effect
-1.72
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDT21 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT21 as an antibody target. Whether an autoantibody or antibody against NUDT21 could matter depends on whether native NUDT21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUDT21. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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