Seroatlas · Human Serome Atlas

GPATCH8

G patch domain-containing protein 8

Also known as: GPATC8, GPTC8_HUMAN, KIAA0553

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKJ3
Gene: GPATCH8
Ensembl: ENSG00000186566
Chromosome: 17
Canonical length: 1502 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

1502 residues, UniProt reviewed canonical sequence.

>Q9UKJ3|GPATCH8
     1  MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK HGWKLGQGLG
    61  KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV LEVEKEDTEE LRQKYKDYVD
   121  KEKAIAKALE DLRANFYCEL CDKQYQKHQE FDNHINSYDH AHKQRLKDLK QREFARNVSS
   181  RSRKDEKKQE KALRRLHELA EQRKQAECAP GSGPMFKPTT VAVDEEGGED DKDESATNSG
   241  TGATASCGLG SEFSTDKGGP FTAVQITNTT GLAQAPGLAS QGISFGIKNN LGTPLQKLGV
   301  SFSFAKKAPV KLESIASVFK DHAEEGTSED GTKPDEKSSD QGLQKVGDSD GSSNLDGKKE
   361  DEDPQDGGSL ASTLSKLKRM KREEGAGATE PEYYHYIPPA HCKVKPNFPF LLFMRASEQM
   421  DGDNTTHPKN APESKKGSSP KPKSCIKAAA SQGAEKTVSE VSEQPKETSM TEPSEPGSKA
   481  EAKKALGGDV SDQSLESHSQ KVSETQMCES NSSKETSLAT PAGKESQEGP KHPTGPFFPV
   541  LSKDESTALQ WPSELLIFTK AEPSISYSCN PLYFDFKLSR NKDARTKGTE KPKDIGSSSK
   601  DHLQGLDPGE PNKSKEVGGE KIVRSSGGRM DAPASGSACS GLNKQEPGGS HGSETEDTGR
   661  SLPSKKERSG KSHRHKKKKK HKKSSKHKRK HKADTEEKSS KAESGEKSKK RKKRKRKKNK
   721  SSAPADSERG PKPEPPGSGS PAPPRRRRRA QDDSQRRSLP AEEGSSGKKD EGGGGSSSQD
   781  HGGRKHKGEL PPSSCQRRAG TKRSSRSSHR SQPSSGDEDS DDASSHRLHQ KSPSQYSEEE
   841  EEEDSGSEHS RSRSRSGRRH SSHRSSRRSY SSSSDASSDQ SCYSRQRSYS DDSYSDYSDR
   901  SRRHSKRSHD SDDSDYASSK HRSKRHKYSS SDDDYSLSCS QSRSRSRSHT RERSRSRGRS
   961  RSSSCSRSRS KRRSRSTTAH SWQRSRSYSR DRSRSTRSPS QRSGSRKRSW GHESPEERHS
  1021  GRRDFIRSKI YRSQSPHYFR SGRGEGPGKK DDGRGDDSKA TGPPSQNSNI GTGRGSEGDC
  1081  SPEDKNSVTA KLLLEKIQSR KVERKPSVSE EVQATPNKAG PKLKDPPQGY FGPKLPPSLG
  1141  NKPVLPLIGK LPATRKPNKK CEESGLERGE EQEQSETEEG PPGSSDALFG HQFPSEETTG
  1201  PLLDPPPEES KSGEATADHP VAPLGTPAHS DCYPGDPTIS HNYLPDPSDG DTLESLDSSS
  1261  QPGPVESSLL PIAPDLEHFP SYAPPSGDPS IESTDGAEDA SLAPLESQPI TFTPEEMEKY
  1321  SKLQQAAQQH IQQQLLAKQV KAFPASAALA PATPALQPIH IQQPATASAT SITTVQHAIL
  1381  QHHAAAAAAA IGIHPHPHPQ PLAQVHHIPQ PHLTPISLSH LTHSIIPGHP ATFLASHPIH
  1441  IIPASAIHPG PFTFHPVPHA ALYPTLLAPR PAAAAATALH LHPLLHPIFS GQDLQHPPSH
  1501  GT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPATCH8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 49 nTPM
skeletal muscle: 40 nTPM
retina: 28 nTPM
ovary: 21 nTPM
pituitary gland: 19 nTPM
thymus: 19 nTPM

Single-cell type

myonuclei: 1,703 nCPM
thyrotrophs: 512 nCPM
nk-cells: 501 nCPM
lactotrophs: 498 nCPM
corticotrophs: 475 nCPM
retinal horizontal cells: 473 nCPM

Immune cell

non-classical monocyte: 14 nTPM
NK-cell: 10 nTPM
gdT-cell: 9.4 nTPM
MAIT T-cell: 8.7 nTPM
memory B-cell: 8.6 nTPM
basophil: 8.2 nTPM

Brain region

cerebellum: 20 nTPM
white matter: 16 nTPM
basal ganglia: 16 nTPM
medulla oblongata: 16 nTPM
thalamus: 16 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPATCH8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RNPS1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPATCH8 as an antibody target. Whether an autoantibody or antibody against GPATCH8 could matter depends on whether native GPATCH8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPATCH8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPATCH8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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