Seroatlas · Human Serome Atlas

MAGOH

Protein mago nashi homolog

Also known as: MAGOH1, MAGOHA, MGN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61326
Gene: MAGOH
Ensembl: ENSG00000162385
Chromosome: 1
Canonical length: 146 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>P61326|MAGOH
     1  MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL
    61  KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR
   121  VFYYLVQDLK CLVFSLIGLH FKIKPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGOH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 133 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 133 nTPM
thymus: 95 nTPM
tonsil: 81 nTPM
lymph node: 79 nTPM
liver: 71 nTPM
placenta: 64 nTPM

Single-cell type

syncytiotrophoblasts: 280 nCPM
migrating cytotrophoblasts: 245 nCPM
cytotrophoblasts: 245 nCPM
extravillous trophoblasts: 224 nCPM
oocytes: 203 nCPM
esophageal basal cells: 186 nCPM

Immune cell

plasmacytoid DC: 59 nTPM
T-reg: 54 nTPM
eosinophil: 54 nTPM
NK-cell: 53 nTPM
intermediate monocyte: 52 nTPM
memory CD8 T-cell: 52 nTPM

Brain region

choroid plexus: 18 nTPM
hypothalamus: 17 nTPM
medulla oblongata: 17 nTPM
cerebral cortex: 17 nTPM
white matter: 17 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.8
gnomAD missense Z: 2.57
DepMap mean gene effect: -0.97
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAGOH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGOH as an antibody target. Whether an autoantibody or antibody against MAGOH could matter depends on whether native MAGOH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGOH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGOH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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