Seroatlas · Human Serome Atlas

SIGLEC10

Sialic acid-binding Ig-like lectin 10

Also known as: MGC126774, PRO940, SIG10_HUMAN, SIGLEC-10, SLG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96LC7
Gene
SIGLEC10
Ensembl
ENSG00000142512
Chromosome
19
Canonical length
697 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Actin filaments,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>Q96LC7|SIGLEC10
     1  MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW TGSTPAYGYW
    61  FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN CSLVIRDAQM QDESQYFFRV
   121  ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI PETLEPGQPV TVICVFNWAF EECPPPSFSW
   181  TGAALSSQGT KPTTSHFSVL SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD
   241  LVISISRDNT PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP
   301  WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM VSQANRTVLE
   361  NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS PSQPSDPGVL ELPRVQVEHE
   421  GEFTCHARHP LGSQHVSLSL SVHYSPKLLG PSCSWEAEGL HCSCSSQASP APSLRWWLGE
   481  ELLEGNSSQD SFEVTPSSAG PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK
   541  KGLISTAFSN GAFLGIGITA LLFLCLALII MKILPKRRTQ TETPRPRFSR HSTILDYINV
   601  VPTAGPLAQK RNQKATPNSP RTPLPPGAPS PESKKNQKKQ YQLPSFPEPK SSTQAPESQE
   661  SQEELHYATL NFPGVRPRPE ARMPKGTQAD YAEVKFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIGLEC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 46 nTPM
  • appendix: 32 nTPM
  • lymph node: 19 nTPM
  • tonsil: 18 nTPM
  • bone marrow: 14 nTPM
  • small intestine: 14 nTPM

Single-cell type

  • kupffer cells: 139 nCPM
  • monocytes: 76 nCPM
  • macrophages: 67 nCPM
  • neutrophils: 64 nCPM
  • microglia: 55 nCPM
  • cdc: 27 nCPM

Immune cell

  • eosinophil: 767 nTPM
  • non-classical monocyte: 543 nTPM
  • intermediate monocyte: 252 nTPM
  • neutrophil: 88 nTPM
  • classical monocyte: 42 nTPM
  • memory B-cell: 42 nTPM

Brain region

  • medulla oblongata: 28 nTPM
  • white matter: 23 nTPM
  • pons: 22 nTPM
  • cerebral cortex: 19 nTPM
  • spinal cord: 17 nTPM
  • thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
1
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIGLEC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIGLEC10 as an antibody target. Whether an autoantibody or antibody against SIGLEC10 could matter depends on whether native SIGLEC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIGLEC10 is annotated at the cell surface, where native SIGLEC10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIGLEC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIGLEC10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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