Seroatlas · Human Serome Atlas

IFIT3

Interferon-induced protein with tetratricopeptide repeats 3

Also known as: CIG-49, GARG-49, IFI60, IFIT3_HUMAN, IFIT4, IRG2, ISG60, RIG-G

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14879
Gene: IFIT3
Ensembl: ENSG00000119917
Chromosome: 10
Canonical length: 490 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Involved in antiviral innate immune response; negative regulation of apoptotic process; and negative regulation of cell population proliferation. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>O14879|IFIT3
     1  MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK ATMYNLLAYI
    61  KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV
   121  KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM
   181  YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ
   241  TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA
   301  SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS
   361  HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL
   421  QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR
   481  ELLSNSEQLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFIT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

spleen: 45 nTPM
lung: 42 nTPM
bone marrow: 41 nTPM
salivary gland: 32 nTPM
thymus: 31 nTPM
placenta: 29 nTPM

Single-cell type

epididymal basal cells: 413 nCPM
epididymal efferent duct ciliated cells: 114 nCPM
epididymal clear cells: 102 nCPM
endometrial luminal cells: 76 nCPM
oligodendrocytes: 76 nCPM
schwann cells: 76 nCPM

Immune cell

neutrophil: 490 nTPM
eosinophil: 173 nTPM
non-classical monocyte: 125 nTPM
basophil: 106 nTPM
intermediate monocyte: 102 nTPM
classical monocyte: 46 nTPM

Brain region

spinal cord: 88 nTPM
white matter: 78 nTPM
pons: 61 nTPM
medulla oblongata: 61 nTPM
basal ganglia: 55 nTPM
midbrain: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFIT3.

Disease | ImmuneIEDB

Conditions an epitope on IFIT3 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0.12
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFIT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFIT3 as an antibody target. Whether an autoantibody or antibody against IFIT3 could matter depends on whether native IFIT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFIT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFIT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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