Seroatlas · Human Serome Atlas

UBE2N

Ubiquitin-conjugating enzyme E2 N

Also known as: MGC8489, UBC13, UbcH-ben, UBE2N_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61088
Gene
UBE2N
Ensembl
ENSG00000177889
Chromosome
12
Canonical length
152 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>P61088|UBE2N
     1  MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE
    61  EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP
   121  LANDVAEQWK TNEAQAIETA RAWTRLYAMN NI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2N can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
180 nTPM

Expression across tissuesHPA

Tissue

  • testis: 180 nTPM
  • skeletal muscle: 78 nTPM
  • lymph node: 75 nTPM
  • thymus: 74 nTPM
  • urinary bladder: 71 nTPM
  • tonsil: 69 nTPM

Single-cell type

  • late spermatids: 13,825 nCPM
  • early spermatids: 2,775 nCPM
  • late primary spermatocytes: 1,192 nCPM
  • esophageal apical cells: 413 nCPM
  • syncytiotrophoblasts: 341 nCPM
  • migrating cytotrophoblasts: 299 nCPM

Immune cell

  • total PBMC: 203 nTPM
  • T-reg: 199 nTPM
  • memory B-cell: 175 nTPM
  • naive B-cell: 146 nTPM
  • non-classical monocyte: 142 nTPM
  • basophil: 134 nTPM

Brain region

  • hypothalamus: 101 nTPM
  • pons: 99 nTPM
  • cerebral cortex: 93 nTPM
  • basal ganglia: 91 nTPM
  • medulla oblongata: 83 nTPM
  • white matter: 82 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.88
gnomAD missense Z
2.51
DepMap mean gene effect
-1.08
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2N in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2N as an antibody target. Whether an autoantibody or antibody against UBE2N could matter depends on whether native UBE2N is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2N is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2N as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2N. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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