Seroatlas · Human Serome Atlas

SEC14L1

SEC14-like protein 1

Also known as: PRELID4A, S14L1_HUMAN, SEC14L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92503
Gene: SEC14L1
Ensembl: ENSG00000129657
Chromosome: 17
Canonical length: 715 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q92503|SEC14L1
     1  MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG AIHVIERRCK
    61  LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE TFSNRVIINE HCCYTVHPEN
   121  EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK QYTSNIKKGK EIIEYYLRQL EEEGITFVPR
   181  WSPPSITTSS ETSSSSSKKQ AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD
   241  ADYIKRYLGD LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ
   301  SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD TKGLVRALGE
   361  EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG LNMRHLWRPG VKALLRIIEV
   421  VEANYPETLG RLLILRAPRV FPVLWTLVSP FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK
   481  EIIPDFLSGE CMCEVPEGGL VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI
   541  QIVDASSVIT WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ
   601  LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP RVDDVLASLQ
   661  VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA TTSSSQSHSS SMISR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC14L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 88 nTPM
placenta: 72 nTPM
bone marrow: 62 nTPM
adipose tissue: 61 nTPM
lung: 58 nTPM
cerebellum: 52 nTPM

Single-cell type

late spermatids: 1,361 nCPM
neutrophils: 1,194 nCPM
platelets: 851 nCPM
breast lactating cells: 799 nCPM
endometrial glandular cells: 529 nCPM
vascular endothelial cells: 450 nCPM

Immune cell

neutrophil: 357 nTPM
eosinophil: 49 nTPM
basophil: 34 nTPM
non-classical monocyte: 33 nTPM
intermediate monocyte: 28 nTPM
classical monocyte: 19 nTPM

Brain region

cerebellum: 173 nTPM
thalamus: 154 nTPM
medulla oblongata: 152 nTPM
midbrain: 149 nTPM
basal ganglia: 148 nTPM
cerebral cortex: 145 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.63
gnomAD missense Z: 2.43
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC14L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC14L1 as an antibody target. Whether an autoantibody or antibody against SEC14L1 could matter depends on whether native SEC14L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC14L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC14L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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