IFI6

Protein identityUniProt · HPA

UniProt accession

P09912

Gene

IFI6

Ensembl

ENSG00000126709

Chromosome

1

Canonical length

130 aa

Protein class

Predicted membrane proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>P09912|IFI6
     1  MRQKAVSLFL CYLLLFTCSG VEAGKKKCSE SSDSGSGFWK ALTFMAVGGG LAVAGLPALG
    61  FTGAGIAANS VAASLMSWSA ILNGGGVPAG GLVATLQSLG AGGSSVVIGN IGALMGYATH
   121  KYLDSEEDEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFI6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

3,350 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFI6.

Disease | ImmuneIEDB

Conditions an epitope on IFI6 was assayed in.

• measles T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.65

gnomAD pLI

0.01

gnomAD missense Z

1.32

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cellular response to virus
• defense response to virus
• immune response
• innate immune response
• intrinsic apoptotic signaling pathway
• negative regulation of apoptotic process
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• negative regulation of mitochondrial depolarization
• negative regulation of release of cytochrome c from mitochondria
• reactive oxygen species metabolic process
• regulation of epidermal growth factor receptor signaling pathway

Molecular functions

• molecular adaptor activity

Cellular components

• endoplasmic reticulum membrane
• mitochondrial inner membrane
• mitochondrial membrane
• mitochondrial outer membrane
• mitochondrion
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Interferon alpha-inducible protein IFI6/IFI27-like
• IFI6/IFI27-like domain superfamily
• Interferon-induced 6-16 family

KeywordsUniProt

• Antiviral defense
• Apoptosis
• Endoplasmic reticulum
• Immunity
• Innate immunity
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of IFI6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CIB1
• RIGI