Seroatlas · Human Serome Atlas

PTPN11

Tyrosine-protein phosphatase non-receptor type 11

Also known as: BPTP3, NS1, PTN11_HUMAN, PTP2C, SH-PTP2, SHP-2, SHP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06124
Gene
PTPN11
Ensembl
ENSG00000179295
Chromosome
12
Canonical length
593 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Nucleoli rim,Actin filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q06124|PTPN11
     1  MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG
    61  DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK
   121  EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD
   181  VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT
   241  DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP
   301  VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV
   361  ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF
   421  RTWPDHGVPS DPGGVLDFLE EVHHKQESIM DAGPVVVHCS AGIGRTGTFI VIDILIDIIR
   481  EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH
   541  EYTNIKYSLA DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQK SFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPN11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 65 nTPM
  • heart muscle: 63 nTPM
  • skeletal muscle: 61 nTPM
  • tongue: 59 nTPM
  • adipose tissue: 55 nTPM
  • parathyroid gland: 50 nTPM

Single-cell type

  • hepatocytes: 152 nCPM
  • thymic myoid cells: 147 nCPM
  • megakaryocyte progenitors: 141 nCPM
  • alveolar cells type 2: 139 nCPM
  • early spermatids: 139 nCPM
  • myonuclei: 133 nCPM

Immune cell

  • basophil: 21 nTPM
  • naive B-cell: 12 nTPM
  • memory B-cell: 10 nTPM
  • plasmacytoid DC: 10 nTPM
  • non-classical monocyte: 9.5 nTPM
  • naive CD4 T-cell: 9 nTPM

Brain region

  • white matter: 241 nTPM
  • basal ganglia: 214 nTPM
  • spinal cord: 210 nTPM
  • midbrain: 206 nTPM
  • medulla oblongata: 205 nTPM
  • hypothalamus: 203 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTPN11.

Disease | AllUniProt

Conditions PTPN11 is implicated in, by any mechanism.

Disease | GeneticClinVar

196 pathogenic / likely-pathogenic of 1,332 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
3.13
DepMap mean gene effect
-0.77
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTPN11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTPN11 as an antibody target. Whether an autoantibody or antibody against PTPN11 could matter depends on whether native PTPN11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTPN11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTPN11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTPN11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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