Seroatlas · Human Serome Atlas

CYLD

Ubiquitin carboxyl-terminal hydrolase CYLD

Also known as: CYLD_HUMAN, CYLD1, KIAA0849, USPL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQC7
Gene
CYLD
Ensembl
ENSG00000083799
Chromosome
16
Canonical length
956 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium transition zone,Centriolar satellite,Basal body,Principal piece

OverviewNCBI Gene

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

956 residues, UniProt reviewed canonical sequence.

>Q9NQC7|CYLD
     1  MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI
    61  PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS
   121  KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG PLLAERTVSG IFFGVELLEE GRGQGFTDGV
   181  YQGKQLFQCD EDCGVFVALD KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV
   241  GETIESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN
   301  DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN RSELFYTLNG
   361  SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP PLQPPPVNSL TTENRFHSLP
   421  FSLTKMPNTN GSIGHSPLSL SAQSVMEELN TAPVQESPPL AMPPGNSHGL EVGSLAEVKE
   481  NPPFYGVIRW IGQPPGLNEV LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR
   541  PDSRFASLQP VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS
   601  CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI YGYVCATKIM
   661  KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL KIRSAGQKVQ DCYFYQIFME
   721  KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS CLIIQMPRFG KDFKLFKKIF PSLELNITDL
   781  LEDTPRQCRI CGGLAMYECR ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL
   841  PKDLPDWDWR HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG
   901  FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP TMSLYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYLD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 89 nTPM
  • lymph node: 50 nTPM
  • tonsil: 45 nTPM
  • spleen: 37 nTPM
  • appendix: 37 nTPM
  • testis: 36 nTPM

Single-cell type

  • neutrophils: 362 nCPM
  • t-cells: 171 nCPM
  • neutrophil progenitors: 167 nCPM
  • suprabasal keratinocytes: 165 nCPM
  • ocular epithelial cells: 155 nCPM
  • b-cells: 148 nCPM

Immune cell

  • basophil: 65 nTPM
  • eosinophil: 38 nTPM
  • T-reg: 38 nTPM
  • neutrophil: 32 nTPM
  • memory CD4 T-cell: 27 nTPM
  • NK-cell: 26 nTPM

Brain region

  • thalamus: 79 nTPM
  • midbrain: 69 nTPM
  • pons: 60 nTPM
  • amygdala: 60 nTPM
  • hypothalamus: 59 nTPM
  • basal ganglia: 58 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CYLD.

Disease | AllUniProt

Conditions CYLD is implicated in, by any mechanism.

  • Cylindromatosis, familial (FCYL) MIM:132700
  • Trichoepithelioma, multiple familial, 1 (MFT1) MIM:601606
  • Brooke-Spiegler syndrome (BRSS) MIM:605041
  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 (FTDALS8) MIM:619132

Disease | GeneticClinVar

74 pathogenic / likely-pathogenic of 444 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Familial cylindromatosis
  • Brooke-Spiegler syndrome
  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 8
  • Familial multiple trichoepitheliomata
  • Trichoepithelioma, multiple familial, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
3.55
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYLD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYLD as an antibody target. Whether an autoantibody or antibody against CYLD could matter depends on whether native CYLD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYLD is annotated at the cell surface, where native CYLD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CYLD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYLD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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