Seroatlas · Human Serome Atlas

RNF125

E3 ubiquitin-protein ligase RNF125

Also known as: FLJ20456, RN125_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EQ8
Gene
RNF125
Ensembl
ENSG00000101695
Chromosome
18
Canonical length
232 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoli,Golgi apparatus

OverviewNCBI Gene

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>Q96EQ8|RNF125
     1  MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC
    61  IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDTLVCLS EMRAHIRTCQ
   121  KYIDKYGPLQ ELEETAARCV CPFCQRELYE DSLLDHCITH HRSERRPVFC PLCRLIPDEN
   181  PSSFSGSLIR HLQVSHTLFY DDFIDFNIIE EALIRRVLDR SLLEYVNHSN TT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF125 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 17 nTPM
  • liver: 12 nTPM
  • small intestine: 11 nTPM
  • duodenum: 9.8 nTPM
  • adipose tissue: 9.5 nTPM
  • breast: 6.5 nTPM

Single-cell type

  • early spermatids: 121 nCPM
  • microglia: 88 nCPM
  • oligodendrocytes: 71 nCPM
  • nk-cells: 47 nCPM
  • renal collecting duct principal cells: 26 nCPM
  • proximal tubule cells: 26 nCPM

Immune cell

  • NK-cell: 16 nTPM
  • gdT-cell: 15 nTPM
  • T-reg: 14 nTPM
  • basophil: 13 nTPM
  • memory CD8 T-cell: 13 nTPM
  • naive CD8 T-cell: 12 nTPM

Brain region

  • white matter: 16 nTPM
  • medulla oblongata: 11 nTPM
  • thalamus: 11 nTPM
  • basal ganglia: 11 nTPM
  • pons: 10 nTPM
  • midbrain: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF125.

Disease | AllUniProt

Conditions RNF125 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 99 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Tenorio syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF125 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF125 as an antibody target. Whether an autoantibody or antibody against RNF125 could matter depends on whether native RNF125 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF125 is annotated at the cell surface, where native RNF125 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RNF125 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF125. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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