Seroatlas · Human Serome Atlas

LRRC25

Leucine-rich repeat-containing protein 25

Also known as: FLJ38116, LRC25_HUMAN, MAPA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N386
Gene: LRRC25
Ensembl: ENSG00000175489
Chromosome: 19
Canonical length: 305 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Microtubules,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including canonical NF-kappaB signal transduction; connective tissue replacement involved in inflammatory response wound healing; and response to angiotensin. Located in cytosol; endoplasmic reticulum; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q8N386|LRRC25
     1  MGGTLAWTLL LPLLLRESDS LEPSCTVSSA DVDWNAEFSA TCLNFSGLSL SLPHNQSLRA
    61  SNVILLDLSG NGLRELPVTF FAHLQKLEVL NVLRNPLSRV DGALAARCDL DLQADCNCAL
   121  ESWHDIRRDN CSGQKPLLCW DTTSSQHNLS AFLEVSCAPG LASATIGAVV VSGCLLLGLA
   181  IAGPVLAWRL WRCRVARSRE LNKPWAAQDG PKPGLGLQPR YGSRSAPKPQ VAVPSCPSTP
   241  DYENMFVGQP AAEHQWDEQG AHPSEDNDFY INYKDIDLAS QPVYCNLQSL GQAPMDEEEY
   301  VIPGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

spleen: 59 nTPM
bone marrow: 31 nTPM
appendix: 21 nTPM
lung: 11 nTPM
lymph node: 9.3 nTPM
adipose tissue: 8.9 nTPM

Single-cell type

neutrophils: 171 nCPM
kupffer cells: 131 nCPM
monocytes: 106 nCPM
macrophages: 55 nCPM
cdc: 42 nCPM
monocyte progenitors: 36 nCPM

Immune cell

non-classical monocyte: 710 nTPM
neutrophil: 575 nTPM
intermediate monocyte: 512 nTPM
eosinophil: 357 nTPM
classical monocyte: 321 nTPM
myeloid DC: 230 nTPM

Brain region

thalamus: 16 nTPM
medulla oblongata: 14 nTPM
white matter: 14 nTPM
pons: 13 nTPM
cerebral cortex: 12 nTPM
choroid plexus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.95
gnomAD missense Z: 0.81
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat domain superfamily
Leucine-rich repeat-containing protein 25

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC25 as an antibody target. Whether an autoantibody or antibody against LRRC25 could matter depends on whether native LRRC25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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