Seroatlas · Human Serome Atlas

WDR26

WD repeat-containing protein 26

Also known as: FLJ21016, GID7, WDR26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7D7
Gene: WDR26
Ensembl: ENSG00000162923
Chromosome: 1
Canonical length: 661 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

661 residues, UniProt reviewed canonical sequence.

>Q9H7D7|WDR26
     1  MQANGAGGGG GGGGGGGGGG GGGGGQGQTP ELACLSAQNG ESSPSSSSSA GDLAHANGLL
    61  PSAPSAASNN SNSLNVNNGV PGGAAAASSA TVAAASATTA ASSSLATPEL GSSLKKKKRL
   121  SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG DWDKAENDLN
   181  ELKPLVHSPH AIVVRGALEI SQTLLGIIVR MKFLLLQQKY LEYLEDGKVL EALQVLRCEL
   241  TPLKYNTERI HVLSGYLMCS HAEDLRAKAE WEGKGTASRS KLLDKLQTYL PPSVMLPPRR
   301  LQTLLRQAVE LQRDRCLYHN TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI LTEHCNEVWF
   361  CKFSNDGTKL ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH AYGVSYIAWS PDDNYLVACG
   421  PDDCSELWLW NVQTGELRTK MSQSHEDSLT SVAWNPDGKR FVTGGQRGQF YQCDLDGNLL
   481  DSWEGVRVQC LWCLSDGKTV LASDTHQRIR GYNFEDLTDR NIVQEDHPIM SFTISKNGRL
   541  ALLNVATQGV HLWDLQDRVL VRKYQGVTQG FYTIHSCFGG HNEDFIASGS EDHKVYIWHK
   601  RSELPIAELT GHTRTVNCVS WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ NIEEECSSMD
   661  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 65 nTPM
skeletal muscle: 59 nTPM
esophagus: 58 nTPM
skin: 50 nTPM
lung: 40 nTPM
spleen: 39 nTPM

Single-cell type

neutrophils: 1,159 nCPM
esophageal apical cells: 881 nCPM
early spermatids: 395 nCPM
neutrophil progenitors: 363 nCPM
kupffer cells: 363 nCPM
monocytes: 320 nCPM

Immune cell

neutrophil: 2.9 nTPM
basophil: 1.3 nTPM
eosinophil: 1.2 nTPM
intermediate monocyte: 1 nTPM
non-classical monocyte: 1 nTPM
plasmacytoid DC: 0.8 nTPM

Brain region

choroid plexus: 71 nTPM
medulla oblongata: 64 nTPM
hippocampal formation: 63 nTPM
thalamus: 63 nTPM
amygdala: 62 nTPM
hypothalamus: 62 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR26.

Disease | AllUniProt

Conditions WDR26 is implicated in, by any mechanism.

Skraban-Deardorff syndrome (SKDEAS) MIM:617616

Disease | GeneticClinVar

62 pathogenic / likely-pathogenic of 286 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Skraban-Deardorff syndrome
Inborn genetic diseases
Intellectual disability
Intellectual disability, seizures, abnormal gait and distinctive facial features
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.09
gnomAD pLI: 1
gnomAD missense Z: 3.58
DepMap mean gene effect: -0.5
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR26 as an antibody target. Whether an autoantibody or antibody against WDR26 could matter depends on whether native WDR26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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