Seroatlas · Human Serome Atlas

USP11

Ubiquitin carboxyl-terminal hydrolase 11

Also known as: UBP11_HUMAN, UHX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51784
Gene: USP11
Ensembl: ENSG00000102226
Chromosome: X
Canonical length: 963 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

963 residues, UniProt reviewed canonical sequence.

>P51784|USP11
     1  MAVAPRLFGG LCFRFRDQNP EVAVEGRLPI SHSCVGCRRE RTAMATVAAN PAAAAAAVAA
    61  AAAVTEDREP QHEELPGLDS QWRQIENGES GRERPLRAGE SWFLVEKHWY KQWEAYVQGG
   121  DQDSSTFPGC INNATLFQDE INWRLKEGLV EGEDYVLLPA AAWHYLVSWY GLEHGQPPIE
   181  RKVIELPNIQ KVEVYPVELL LVRHNDLGKS HTVQFSHTDS IGLVLRTARE RFLVEPQEDT
   241  RLWAKNSEGS LDRLYDTHIT VLDAALETGQ LIIMETRKKD GTWPSAQLHV MNNNMSEEDE
   301  DFKGQPGICG LTNLGNTCFM NSALQCLSNV PQLTEYFLNN CYLEELNFRN PLGMKGEIAE
   361  AYADLVKQAW SGHHRSIVPH VFKNKVGHFA SQFLGYQQHD SQELLSFLLD GLHEDLNRVK
   421  KKEYVELCDA AGRPDQEVAQ EAWQNHKRRN DSVIVDTFHG LFKSTLVCPD CGNVSVTFDP
   481  FCYLSVPLPI SHKRVLEVFF IPMDPRRKPE QHRLVVPKKG KISDLCVALS KHTGISPERM
   541  MVADVFSHRF YKLYQLEEPL SSILDRDDIF VYEVSGRIEA IEGSREDIVV PVYLRERTPA
   601  RDYNNSYYGL MLFGHPLLVS VPRDRFTWEG LYNVLMYRLS RYVTKPNSDD EDDGDEKEDD
   661  EEDKDDVPGP STGGSLRDPE PEQAGPSSGV TNRCPFLLDN CLGTSQWPPR RRRKQLFTLQ
   721  TVNSNGTSDR TTSPEEVHAQ PYIAIDWEPE MKKRYYDEVE AEGYVKHDCV GYVMKKAPVR
   781  LQECIELFTT VETLEKENPW YCPSCKQHQL ATKKLDLWML PEILIIHLKR FSYTKFSREK
   841  LDTLVEFPIR DLDFSEFVIQ PQNESNPELY KYDLIAVSNH YGGMRDGHYT TFACNKDSGQ
   901  WHYFDDNSVS PVNENQIESK AAYVLFYQRQ DVARRLLSPA GSSGAPASPA CSSPPSSEFM
   961  DVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 169 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 169 nTPM
basal ganglia: 145 nTPM
hypothalamus: 133 nTPM
cerebellum: 114 nTPM
pituitary gland: 105 nTPM
amygdala: 99 nTPM

Single-cell type

undifferentiated spermatogonia: 133 nCPM
retinal bipolar cells: 130 nCPM
other brain neurons: 125 nCPM
brain inhibitory neurons: 107 nCPM
retinal amacrine cells: 101 nCPM
corticotrophs: 97 nCPM

Immune cell

naive CD8 T-cell: 77 nTPM
basophil: 64 nTPM
NK-cell: 56 nTPM
gdT-cell: 56 nTPM
memory CD8 T-cell: 54 nTPM
memory B-cell: 53 nTPM

Brain region

hypothalamus: 350 nTPM
basal ganglia: 281 nTPM
cerebral cortex: 276 nTPM
pons: 239 nTPM
midbrain: 207 nTPM
thalamus: 206 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about USP11.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 176 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Abnormal brain morphology
Dynein arm defect of respiratory motile cilia
Absent inner and outer dynein arms
Abnormal ciliary motility
Bronchiectasis

Disease | ImmuneIEDB

Conditions an epitope on USP11 was assayed in.

glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.57
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USP11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP11 as an antibody target. Whether an autoantibody or antibody against USP11 could matter depends on whether native USP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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