Seroatlas · Human Serome Atlas

SNRPF

Small nuclear ribonucleoprotein F

Also known as: RUXF_HUMAN, Sm-F

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62306
Gene: SNRPF
Ensembl: ENSG00000139343
Chromosome: 12
Canonical length: 86 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in spliceosomal snRNP assembly. Located in cytosol and nucleus. Part of several cellular components, including methylosome; nucleus; and pICln-Sm protein complex. Biomarker of nasopharynx carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

86 residues, UniProt reviewed canonical sequence.

>P62306|SNRPF
     1  MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG
    61  EVLIRCNNVL YIRGVEEEEE DGEMRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 178 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 178 nTPM
esophagus: 167 nTPM
thymus: 160 nTPM
liver: 138 nTPM
tonsil: 135 nTPM
lymph node: 128 nTPM

Single-cell type

esophageal basal cells: 644 nCPM
gastric progenitor cells: 610 nCPM
extravillous trophoblasts: 522 nCPM
migrating cytotrophoblasts: 484 nCPM
esophageal suprabasal cells: 442 nCPM
cytotrophoblasts: 420 nCPM

Immune cell

myeloid DC: 217 nTPM
plasmacytoid DC: 211 nTPM
memory B-cell: 178 nTPM
naive CD4 T-cell: 178 nTPM
memory CD4 T-cell: 167 nTPM
MAIT T-cell: 163 nTPM

Brain region

hypothalamus: 35 nTPM
midbrain: 32 nTPM
cerebellum: 32 nTPM
pons: 29 nTPM
cerebral cortex: 28 nTPM
medulla oblongata: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.79
gnomAD missense Z: 1.88
DepMap mean gene effect: -2.85
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPF as an antibody target. Whether an autoantibody or antibody against SNRPF could matter depends on whether native SNRPF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRPF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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