Seroatlas · Human Serome Atlas

TEX19

Testis-expressed protein 19

Also known as: FLJ35767, TEX19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA77
Gene: TEX19
Ensembl: ENSG00000182459
Chromosome: 17
Canonical length: 164 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable piRNA binding activity. Involved in transposable element silencing. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q8NA77|TEX19
     1  MCPPVSMRYE EEGMSYLYAS WMYQLQHGDQ LSICFTCFKA AFLDFKDLLE SEDWEEDNWD
    61  PELMEHTEAE SEQEGSSGME LSWGQSPGQP VQGGSEAWGP GTLAAAPEGL EDAGLDPHFV
   121  PTELWPQEAV PLGLGLEDAD WTQGLPWRFE ELLTCSHWPS FFPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
thymus: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early primary spermatocytes: 405 nCPM
differentiating spermatogonia: 25 nCPM
late spermatids: 3.5 nCPM
late primary spermatocytes: 1.4 nCPM
pdcs: 0.6 nCPM
sertoli cells: 0.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.32
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

piRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Testis-expressed protein 19
Testis-expressed protein 19

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX19 as an antibody target. Whether an autoantibody or antibody against TEX19 could matter depends on whether native TEX19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...