RMND5B
E3 ubiquitin-protein transferase RMND5B
Also known as: FLJ22318, GID2, GID2B, RMD5B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96G75
- Gene
- RMND5B
- Ensembl
- ENSG00000145916
- Chromosome
- 5
- Canonical length
- 393 aa
- Protein class
- Enzymes, Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
393 residues, UniProt reviewed canonical sequence.
>Q96G75|RMND5B
1 MEQCACVERE LDKVLQKFLT YGQHCERSLE ELLHYVGQLR AELASAALQG TPLSATLSLV
61 MSQCCRKIKD TVQKLASDHK DIHSSVSRVG KAIDRNFDSE ICGVVSDAVW DAREQQQQIL
121 QMAIVEHLYQ QGMLSVAEEL CQESTLNVDL DFKQPFLELN RILEALHEQD LGPALEWAVS
181 HRQRLLELNS SLEFKLHRLH FIRLLAGGPA KQLEALSYAR HFQPFARLHQ REIQVMMGSL
241 VYLRLGLEKS PYCHLLDSSH WAEICETFTR DACSLLGLSV ESPLSVSFAS GCVALPVLMN
301 IKAVIEQRQC TGVWNHKDEL PIEIELGMKC WYHSVFACPI LRQQTSDSNP PIKLICGHVI
361 SRDALNKLIN GGKLKCPYCP MEQNPADGKR IIFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RMND5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 91 nTPM
Expression across tissuesHPA
Tissue
- testis: 91 nTPM
- esophagus: 71 nTPM
- skeletal muscle: 44 nTPM
- tongue: 30 nTPM
- skin: 30 nTPM
- vagina: 29 nTPM
Single-cell type
- late spermatids: 754 nCPM
- esophageal apical cells: 527 nCPM
- late primary spermatocytes: 279 nCPM
- early spermatids: 168 nCPM
- esophageal suprabasal cells: 137 nCPM
- retinal ganglion cells: 112 nCPM
Immune cell
- eosinophil: 43 nTPM
- non-classical monocyte: 27 nTPM
- naive B-cell: 25 nTPM
- T-reg: 23 nTPM
- basophil: 22 nTPM
- naive CD4 T-cell: 20 nTPM
Brain region
- medulla oblongata: 32 nTPM
- thalamus: 31 nTPM
- white matter: 28 nTPM
- spinal cord: 27 nTPM
- amygdala: 27 nTPM
- midbrain: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.71
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RMND5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RMND5B as an antibody target. Whether an autoantibody or antibody against RMND5B could matter depends on whether native RMND5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RMND5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RMND5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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