Seroatlas · Human Serome Atlas

YPEL5

Protein yippee-like 5

Also known as: CGI-127, YPEL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62699
Gene: YPEL5
Ensembl: ENSG00000119801
Chromosome: 2
Canonical length: 121 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>P62699|YPEL5
     1  MGRIFLDHIG GTRLFSCANC DTILTNRSEL ISTRFTGATG RAFLFNKVVN LQYSEVQDRV
    61  MLTGRHMVRD VSCKNCNSKL GWIYEFATED SQRYKEGRVI LERALVRESE GFEEHVPSDN
   121  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YPEL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 414 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 414 nTPM
parathyroid gland: 95 nTPM
seminal vesicle: 90 nTPM
blood vessel: 89 nTPM
choroid plexus: 88 nTPM
cerebral cortex: 83 nTPM

Single-cell type

late spermatids: 931 nCPM
neutrophils: 930 nCPM
esophageal apical cells: 652 nCPM
neutrophil progenitors: 550 nCPM
syncytiotrophoblasts: 538 nCPM
b-cells: 468 nCPM

Immune cell

neutrophil: 308 nTPM
basophil: 230 nTPM
eosinophil: 191 nTPM
plasmacytoid DC: 153 nTPM
non-classical monocyte: 150 nTPM
total PBMC: 146 nTPM

Brain region

cerebral cortex: 90 nTPM
choroid plexus: 82 nTPM
hypothalamus: 74 nTPM
basal ganglia: 74 nTPM
medulla oblongata: 73 nTPM
pons: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.46
gnomAD missense Z: 2.29
DepMap mean gene effect: -0.71
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell population proliferation

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YPEL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YPEL5 as an antibody target. Whether an autoantibody or antibody against YPEL5 could matter depends on whether native YPEL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YPEL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YPEL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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