Seroatlas · Human Serome Atlas

GID8

Glucose-induced degradation protein 8 homolog

Also known as: bA305P22.1, C20orf11, FLJ20602, GID8_HUMAN, TWA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWU2
Gene: GID8
Ensembl: ENSG00000101193
Chromosome: 20
Canonical length: 228 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable protein homodimerization activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of cell population proliferation. Located in cell junction; cytosol; and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q9NWU2|GID8
     1  MSYAEKPDEI TKDEWMEKLN NLHVQRADMN RLIMNYLVTE GFKEAAEKFR MESGIEPSVD
    61  LETLDERIKI REMILKGQIQ EAIALINSLH PELLDTNRYL YFHLQQQHLI ELIRQRETEA
   121  ALEFAQTQLA EQGEESRECL TEMERTLALL AFDSPEESPF GDLLHTMQRQ KVWSEVNQAV
   181  LDYENRESTP KLAKLLKLLL WAQNELDQKK VKYPKMTDLS KGVIEEPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GID8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

esophagus: 40 nTPM
bone marrow: 37 nTPM
skin: 29 nTPM
liver: 24 nTPM
thymus: 24 nTPM
ovary: 22 nTPM

Single-cell type

esophageal apical cells: 1,003 nCPM
esophageal suprabasal cells: 236 nCPM
syncytiotrophoblasts: 203 nCPM
extravillous trophoblasts: 138 nCPM
migrating cytotrophoblasts: 128 nCPM
gastric progenitor cells: 128 nCPM

Immune cell

eosinophil: 15 nTPM
neutrophil: 14 nTPM
naive CD8 T-cell: 13 nTPM
NK-cell: 12 nTPM
MAIT T-cell: 12 nTPM
naive CD4 T-cell: 11 nTPM

Brain region

thalamus: 26 nTPM
hippocampal formation: 25 nTPM
spinal cord: 25 nTPM
hypothalamus: 25 nTPM
amygdala: 24 nTPM
midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.94
gnomAD missense Z: 2.47
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 20% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein homodimerization activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GID8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GID8 as an antibody target. Whether an autoantibody or antibody against GID8 could matter depends on whether native GID8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GID8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GID8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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