Seroatlas · Human Serome Atlas

ARMC8

Armadillo repeat-containing protein 8

Also known as: ARMC8_HUMAN, DKFZP434A043, GID5, HSPC056, VID28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUR7
Gene: ARMC8
Ensembl: ENSG00000114098
Chromosome: 3
Canonical length: 673 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>Q8IUR7|ARMC8
     1  MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
    61  GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK
   121  FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH
   181  QTILFNHGAV QNIAHLLTSL SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF
   241  VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
   301  AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
   361  AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT
   421  SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE
   481  NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS
   541  TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL
   601  QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH KLSQSPDSNL
   661  CDKAKMALQQ YLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 57 nTPM
skeletal muscle: 37 nTPM
cerebellum: 36 nTPM
tongue: 32 nTPM
retina: 24 nTPM
blood vessel: 24 nTPM

Single-cell type

neutrophil progenitors: 322 nCPM
myonuclei: 257 nCPM
neutrophils: 256 nCPM
choroid plexus epithelial cells: 224 nCPM
megakaryocyte-erythroid progenitors: 204 nCPM
oligodendrocyte progenitor cells: 198 nCPM

Immune cell

basophil: 80 nTPM
eosinophil: 75 nTPM
T-reg: 51 nTPM
memory B-cell: 49 nTPM
NK-cell: 49 nTPM
non-classical monocyte: 46 nTPM

Brain region

cerebellum: 97 nTPM
choroid plexus: 65 nTPM
white matter: 49 nTPM
pons: 48 nTPM
hypothalamus: 46 nTPM
basal ganglia: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 2.88
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo
Armadillo-like helical
Armadillo-type fold
Armadillo/beta-catenin-like repeat
Armadillo-type fold containing protein ARMC8/Vid28

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMC8 as an antibody target. Whether an autoantibody or antibody against ARMC8 could matter depends on whether native ARMC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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