GID4
Glucose-induced degradation protein 4 homolog
Also known as: C17orf39, GID4_HUMAN, VID24
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IVV7
- Gene
- GID4
- Ensembl
- ENSG00000141034
- Chromosome
- 17
- Canonical length
- 300 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
300 residues, UniProt reviewed canonical sequence.
>Q8IVV7|GID4
1 MCARGQVGRG TQLRTGRPCS QVPGSRWRPE RLLRRQRAGG RPSRPHPARA RPGLSLPATL
61 LGSRAAAAVP LPLPPALAPG DPAMPVRTEC PPPAGASAAS AASLIPPPPI NTQQPGVATS
121 LLYSGSKFRG HQKSKGNSYD VEVVLQHVDT GNSYLCGYLK IKGLTEEYPT LTTFFEGEII
181 SKKHPFLTRK WDADEDVDRK HWGKFLAFYQ YAKSFNSDDF DYEELKNGDY VFMRWKEQFL
241 VPDHTIKDIS GASFAGFYYI CFQKSAASIE GYYYHRSSEW YQSLNLTHVP EHSAPIYEFRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GID4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 68 nTPM
Expression across tissuesHPA
Tissue
- testis: 68 nTPM
- skeletal muscle: 26 nTPM
- tongue: 13 nTPM
- skin: 12 nTPM
- esophagus: 11 nTPM
- blood vessel: 10 nTPM
Single-cell type
- late spermatids: 1,672 nCPM
- early spermatids: 846 nCPM
- late primary spermatocytes: 256 nCPM
- esophageal apical cells: 101 nCPM
- early primary spermatocytes: 45 nCPM
- oocytes: 32 nCPM
Immune cell
- basophil: 3.8 nTPM
- eosinophil: 3.5 nTPM
- memory B-cell: 2.6 nTPM
- neutrophil: 2.5 nTPM
- NK-cell: 1.9 nTPM
- T-reg: 1.9 nTPM
Brain region
- cerebellum: 21 nTPM
- amygdala: 19 nTPM
- thalamus: 18 nTPM
- medulla oblongata: 18 nTPM
- basal ganglia: 17 nTPM
- midbrain: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.38
- gnomAD pLI
- 0.92
- gnomAD missense Z
- 2.1
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- GID complex substrate-recognition subunit 4/10-like
- Vacuolar import and degradation protein
InteractionsUniProt · HPA
Protein binding partners of GID4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GID4 as an antibody target. Whether an autoantibody or antibody against GID4 could matter depends on whether native GID4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GID4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GID4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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