TP73
Tumor protein p73
Also known as: P73, P73_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15350
- Gene
- TP73
- Ensembl
- ENSG00000078900
- Chromosome
- 1
- Canonical length
- 636 aa
- Protein class
- Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Golgi apparatus,Vesicles,Plasma membrane,Cell Junctions,Centrosome,Basal body
OverviewNCBI Gene
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Canonical amino-acid sequenceUniProt
636 residues, UniProt reviewed canonical sequence.
>O15350|TP73
1 MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
61 VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
121 YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
181 YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
241 EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
301 DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
361 GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
421 MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
481 CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
541 IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
601 GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TP73 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 6.3 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 6.3 nTPM
- skin: 6.2 nTPM
- cerebellum: 6 nTPM
- esophagus: 3.5 nTPM
- choroid plexus: 3.4 nTPM
- salivary gland: 2.7 nTPM
Single-cell type
- respiratory deuterosomal cells: 109 nCPM
- respiratory ciliated cells: 101 nCPM
- early spermatids: 79 nCPM
- fallopian tube ciliated cells: 57 nCPM
- endometrial ciliated cells: 55 nCPM
- epididymal efferent duct ciliated cells: 54 nCPM
Immune cell
- eosinophil: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 17 nTPM
- cerebellum: 9.8 nTPM
- midbrain: 6.8 nTPM
- medulla oblongata: 6 nTPM
- spinal cord: 3.7 nTPM
- pons: 3.4 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about TP73.
Disease | AllUniProt
Conditions TP73 is implicated in, by any mechanism.
- Ciliary dyskinesia, primary, 47, and lissencephaly (CILD47) MIM:619466
Disease | GeneticClinVar
6 pathogenic / likely-pathogenic of 144 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Ciliary dyskinesia, primary, 47, and lissencephaly
- Colon adenocarcinoma
- Respiratory failure
Disease | ImmuneIEDB
Conditions an epitope on TP73 was assayed in.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.26
- gnomAD pLI
- 1
- gnomAD missense Z
- 1.85
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cerebrospinal fluid secretion
- digestive tract morphogenesis
- DNA damage response
- hippocampus development
- inflammatory response
- intrinsic apoptotic signaling pathway in response to DNA damage
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- kidney development
- mismatch repair
- negative regulation of cardiac muscle cell proliferation
- negative regulation of cell population proliferation
- negative regulation of neuron apoptotic process
- negative regulation of neuron differentiation
- neuron development
- positive regulation of cell size
- positive regulation of DNA-templated transcription
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- positive regulation of lung ciliated cell differentiation
- positive regulation of MAPK cascade
- positive regulation of oligodendrocyte differentiation
- positive regulation of transcription by RNA polymerase II
- post-embryonic development
- protein tetramerization
- regulation of apoptotic process
- regulation of cell cycle
- regulation of gene expression
- regulation of mitotic cell cycle
- release of cytochrome c from mitochondria
- response to xenobiotic stimulus
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- identical protein binding
- MDM2/MDM4 family protein binding
- metal ion binding
- p53 binding
- promoter-specific chromatin binding
- protein kinase binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- transcription cis-regulatory region binding
- transcription corepressor binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Sterile alpha motif domain
- p53 tumour suppressor family
- p53-like transcription factor, DNA-binding domain superfamily
- p53, tetramerisation domain
- p53, DNA-binding domain
- p53/RUNT-type transcription factor, DNA-binding domain superfamily
- Sterile alpha motif/pointed domain superfamily
- p53-like tetramerisation domain superfamily
- p53, central conserved site
- P53 DNA-binding domain
- SAM domain (Sterile alpha motif)
- P53 tetramerisation motif
- Tumour protein p73, SAM domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TP73 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TP73 as an antibody target. Whether an autoantibody or antibody against TP73 could matter depends on whether native TP73 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TP73 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TP73 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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