S100A7

Protein identityUniProt · HPA

UniProt accession

P31151

Gene

S100A7

Ensembl

ENSG00000143556

Chromosome

1

Canonical length

101 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Cytosol

Secretome location

Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

101 residues, UniProt reviewed canonical sequence.

>P31151|S100A7
     1  MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE
    61  KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

1,901 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for S100A7 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.55

gnomAD pLI

0.45

gnomAD missense Z

-0.49

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• antimicrobial humoral immune response mediated by antimicrobial peptide
• endothelial cell migration
• epidermis development
• keratinocyte differentiation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of granulocyte chemotaxis
• positive regulation of monocyte chemotaxis
• positive regulation of T cell chemotaxis
• response to lipopolysaccharide
• response to reactive oxygen species

Molecular functions

• calcium ion binding
• calcium-dependent protein binding
• RAGE receptor binding
• zinc ion binding
• zinc ion sequestering activity

Cellular components

• azurophil granule lumen
• cytoplasm
• cytosol
• endoplasmic reticulum
• extracellular matrix
• extracellular region
• extracellular space
• focal adhesion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• S100/Calcium binding protein 7/8-like, conserved site
• EF-hand domain
• EF-hand domain pair
• S100/CaBP-9k-type, calcium binding, subdomain
• EF-Hand 1, calcium-binding site
• S-100
• S-100/ICaBP type calcium binding domain

KeywordsUniProt

• Acetylation
• Calcium
• Cytoplasm
• Disulfide bond
• Metal-binding
• Repeat
• Secreted
• Zinc

InteractionsUniProt · HPA

Protein binding partners of S100A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RANBP9
• PINK1