Seroatlas · Human Serome Atlas

MAEA

E3 ubiquitin-protein transferase MAEA

Also known as: EMP, GID9, HLC-10, MAEA_HUMAN, p44EMLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L5Y9
Gene
MAEA
Ensembl
ENSG00000090316
Chromosome
4
Canonical length
396 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q7L5Y9|MAEA
     1  MAVQESAAQL SMTLKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV VAELEKTLSG
    61  CPAVDSVVSL LDGVVEKLSV LKRKAVESIQ AEDESAKLCK RRIEHLKEHS SDQPAAASVW
   121  KRKRMDRMMV EHLLRCGYYN TAVKLARQSG IEDLVNIEMF LTAKEVEESL ERRETATCLA
   181  WCHDNKSRLR KMKSCLEFSL RIQEFIELIR QNKRLDAVRH ARKHFSQAEG SQLDEVRQAM
   241  GMLAFPPDTH ISPYKDLLDP ARWRMLIQQF RYDNYRLHQL GNNSVFTLTL QAGLSAIKTP
   301  QCYKEDGSSK SPDCPVCSRS LNKLAQPLPM AHCANSRLVC KISGDVMNEN NPPMMLPNGY
   361  VYGYNSLLSI RQDDKVVCPR TKEVFHFSQA EKVYIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAEA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 46 nTPM
  • adrenal gland: 43 nTPM
  • kidney: 43 nTPM
  • skin: 40 nTPM
  • spleen: 39 nTPM
  • hypothalamus: 39 nTPM

Single-cell type

  • neutrophils: 283 nCPM
  • syncytiotrophoblasts: 133 nCPM
  • esophageal apical cells: 129 nCPM
  • somatotrophs: 86 nCPM
  • esophageal suprabasal cells: 81 nCPM
  • tuft cells: 69 nCPM

Immune cell

  • neutrophil: 118 nTPM
  • MAIT T-cell: 84 nTPM
  • non-classical monocyte: 78 nTPM
  • basophil: 75 nTPM
  • eosinophil: 71 nTPM
  • T-reg: 60 nTPM

Brain region

  • hypothalamus: 52 nTPM
  • pons: 50 nTPM
  • choroid plexus: 49 nTPM
  • medulla oblongata: 46 nTPM
  • midbrain: 43 nTPM
  • cerebral cortex: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.23
gnomAD missense Z
2.57
DepMap mean gene effect
-0.3
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAEA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAEA as an antibody target. Whether an autoantibody or antibody against MAEA could matter depends on whether native MAEA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAEA is annotated at the cell surface, where native MAEA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAEA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAEA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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