Seroatlas · Human Serome Atlas

RMND5A

E3 ubiquitin-protein transferase RMND5A

Also known as: FLJ13910, GID2, GID2A, p44CTLH, RMD5, RMD5A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H871
Gene
RMND5A
Ensembl
ENSG00000153561
Chromosome
2
Canonical length
391 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q9H871|RMND5A
     1  MDQCVTVERE LEKVLHKFSG YGQLCERGLE ELIDYTGGLK HEILQSHGQD AELSGTLSLV
    61  LTQCCKRIKD TVQKLASDHK DIHSSVSRVG KAIDKNFDSD ISSVGIDGCW QADSQRLLNE
   121  VMVEHFFRQG MLDVAEELCQ ESGLSVDPSQ KEPFVELNRI LEALKVRVLR PALEWAVSNR
   181  EMLIAQNSSL EFKLHRLYFI SLLMGGTTNQ REALQYAKNF QPFALNHQKD IQVLMGSLVY
   241  LRQGIENSPY VHLLDANQWA DICDIFTRDA CALLGLSVES PLSVSFSAGC VALPALINIK
   301  AVIEQRQCTG VWNQKDELPI EVDLGKKCWY HSIFACPILR QQTTDNNPPM KLVCGHIISR
   361  DALNKMFNGS KLKCPYCPME QSPGDAKQIF F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RMND5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 63 nTPM
  • skeletal muscle: 60 nTPM
  • liver: 40 nTPM
  • heart muscle: 36 nTPM
  • tongue: 35 nTPM
  • esophagus: 31 nTPM

Single-cell type

  • esophageal apical cells: 488 nCPM
  • neutrophils: 151 nCPM
  • erythrocyte progenitors: 136 nCPM
  • thymic myoid cells: 107 nCPM
  • megakaryocyte-erythroid progenitors: 104 nCPM
  • hepatocytes: 101 nCPM

Immune cell

  • basophil: 38 nTPM
  • neutrophil: 28 nTPM
  • non-classical monocyte: 13 nTPM
  • classical monocyte: 12 nTPM
  • naive CD8 T-cell: 12 nTPM
  • intermediate monocyte: 10 nTPM

Brain region

  • cerebellum: 108 nTPM
  • white matter: 53 nTPM
  • basal ganglia: 45 nTPM
  • cerebral cortex: 42 nTPM
  • hippocampal formation: 40 nTPM
  • midbrain: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.9
gnomAD missense Z
2.67
DepMap mean gene effect
-0.33
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RMND5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RMND5A as an antibody target. Whether an autoantibody or antibody against RMND5A could matter depends on whether native RMND5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RMND5A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RMND5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RMND5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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