CALB1

Protein identityUniProt · HPA

UniProt accession

P05937

Gene

CALB1

Ensembl

ENSG00000104327

Chromosome

8

Canonical length

261 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>P05937|CALB1
     1  MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT
    61  FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET
   121  EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK
   181  FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA
   241  LSDGGKLYRT DLALILCAGD N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

300 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.51

gnomAD pLI

0.24

gnomAD missense Z

1.44

DepMap mean gene effect

0.16

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cochlea development
• locomotory behavior
• long-term memory
• metanephric collecting duct development
• metanephric distal convoluted tubule development
• metanephric part of ureteric bud development
• regulation of synaptic plasticity
• response to auditory stimulus
• retina layer formation
• short-term memory
• metanephric connecting tubule development

Molecular functions

• calcium ion binding
• calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
• vitamin D binding
• zinc ion binding
• calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration

Cellular components

• axon
• calyx of Held
• cuticular plate
• cytosol
• dendrite
• extracellular exosome
• GABA-ergic synapse
• glutamatergic synapse
• hippocampal mossy fiber to CA3 synapse
• neuronal cell body
• nucleus
• postsynaptic cytosol
• presynaptic cytosol
• stereocilium
• synapse
• terminal bouton

Protein domainsUniProt · Pfam · InterPro

• EF-hand domain
• EF-hand domain pair
• EF-Hand 1, calcium-binding site
• Calbindin Calcium-Binding
• EF hand domain
• EF-hand domain pair
• Calbindin, six-EF hands domain

KeywordsUniProt

• Acetylation
• Calcium
• Metal-binding
• Repeat
• Vitamin D

InteractionsUniProt · HPA

Protein binding partners of CALB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RANBP9
• IKBKG