Seroatlas · Human Serome Atlas

ENTPD1

Ectonucleoside triphosphate diphosphohydrolase 1

Also known as: ATPDase, CD39, ENTP1_HUMAN, NTPDase-1, SPG64

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49961
Gene
ENTPD1
Ensembl
ENSG00000138185
Chromosome
10
Canonical length
510 aa
Protein class
CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins
Subcellular location
Microtubules
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>P49961|ENTPD1
     1  MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT
    61  SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ
   121  HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI
   181  TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR
   241  LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP
   301  CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF
   361  SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL
   421  SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL
   481  MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 46 nTPM
  • blood vessel: 41 nTPM
  • urinary bladder: 29 nTPM
  • endometrium: 26 nTPM
  • bone marrow: 26 nTPM
  • gallbladder: 26 nTPM

Single-cell type

  • neutrophil progenitors: 989 nCPM
  • neutrophils: 978 nCPM
  • microglia: 634 nCPM
  • cdc: 342 nCPM
  • macrophages: 198 nCPM
  • vascular endothelial cells: 141 nCPM

Immune cell

  • eosinophil: 102 nTPM
  • neutrophil: 50 nTPM
  • classical monocyte: 41 nTPM
  • myeloid DC: 32 nTPM
  • intermediate monocyte: 27 nTPM
  • total PBMC: 16 nTPM

Brain region

  • medulla oblongata: 26 nTPM
  • pons: 26 nTPM
  • thalamus: 26 nTPM
  • midbrain: 24 nTPM
  • spinal cord: 24 nTPM
  • white matter: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ENTPD1.

Disease | AllUniProt

Conditions ENTPD1 is implicated in, by any mechanism.

  • Spastic paraplegia 64, autosomal recessive (SPG64) MIM:615683

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 269 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hereditary spastic paraplegia 64
  • ENTPD1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.01
gnomAD missense Z
0.83
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENTPD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTPD1 as an antibody target. Whether an autoantibody or antibody against ENTPD1 could matter depends on whether native ENTPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTPD1 is annotated at the cell surface, where native ENTPD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENTPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENTPD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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