OPRM1

Protein identityUniProt · HPA

UniProt accession

P35372

Gene

OPRM1

Ensembl

ENSG00000112038

Chromosome

6

Canonical length

400 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters

Quaternary structure

Homooligomer

OverviewNCBI Gene

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>P35372|OPRM1
     1  MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP
    61  PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT
   121  STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF
   181  RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI
   241  FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI
   301  YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI
   361  EQQNSTRIRQ NTRDHPSTAN TVDRTNHQLE NLEAETAPLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OPRM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

4.4 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for OPRM1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

-0.62

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• behavioral response to ethanol
• G protein-coupled opioid receptor signaling pathway
• G protein-coupled receptor signaling pathway
• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• negative regulation of cell population proliferation
• negative regulation of cytosolic calcium ion concentration
• negative regulation of nitric oxide biosynthetic process
• neuropeptide signaling pathway
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of neurogenesis
• regulation of cellular response to stress
• regulation of NMDA receptor activity
• sensory perception
• sensory perception of pain
• negative regulation of Wnt protein secretion

Molecular functions

• G protein-coupled receptor activity
• G-protein alpha-subunit binding
• G-protein beta-subunit binding
• neuropeptide binding
• voltage-gated calcium channel activity
• beta-endorphin receptor activity
• morphine receptor activity

Cellular components

• axon
• dendrite
• endoplasmic reticulum
• endosome
• Golgi apparatus
• neuron projection
• perikaryon
• plasma membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Opioid receptor
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• Mu opioid receptor

KeywordsUniProt

• Cell membrane
• Cell projection
• Cytoplasm
• Disulfide bond
• Endosome
• G-protein coupled receptor
• Glycoprotein
• Lipoprotein
• Membrane
• Palmitate
• Phosphoprotein
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of OPRM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLNA
• GNAS
• GPM6A
• HINT1
• PLD2
• PPL
• PPP1R9B
• RANBP9
• RGS17
• RGS20
• RGS4
• RGS9
• RTP4
• SIGMAR1
• SYP
• WLS
• AUP1
• COPS5
• DOK4
• GJA4
• NELFA
• SIAH1
• SIAH2
• VAPA
• ZYX