Seroatlas · Human Serome Atlas

ZMYND19

Zinc finger MYND domain-containing protein 19

Also known as: MIZIP, ZMY19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96E35
Gene: ZMYND19
Ensembl: ENSG00000165724
Chromosome: 9
Canonical length: 227 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 [PubMed 12208518]), and to the N termini of alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 [PubMed 16039987]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q96E35|ZMYND19
     1  MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK IFAYAFDKNR
    61  GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN LQLVPWGWRP KAEETSSKQR
   121  EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY NANGDVVEEE ENSCTYYECH YPPCTVIEKQ
   181  LREFNICGRC QVARYCGSQC QQKDWPAHKK HCRERKRPFQ HELEPER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYND19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 267 nTPM

Expression across tissuesHPA

Tissue

retina: 267 nTPM
testis: 47 nTPM
skin: 26 nTPM
esophagus: 25 nTPM
stomach: 21 nTPM
liver: 20 nTPM

Single-cell type

rod photoreceptor cells: 409 nCPM
cone photoreceptor cells: 110 nCPM
early primary spermatocytes: 31 nCPM
breast lactating cells: 31 nCPM
differentiating spermatogonia: 30 nCPM
undifferentiated spermatogonia: 23 nCPM

Immune cell

intermediate monocyte: 1.6 nTPM
MAIT T-cell: 1.2 nTPM
T-reg: 1 nTPM
plasmacytoid DC: 0.9 nTPM
memory B-cell: 0.8 nTPM
gdT-cell: 0.5 nTPM

Brain region

cerebral cortex: 18 nTPM
hippocampal formation: 15 nTPM
pons: 15 nTPM
basal ganglia: 15 nTPM
hypothalamus: 14 nTPM
white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.95
gnomAD missense Z: 1.56
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, MYND-type
HNH nuclease
His-Me finger superfamily
MYND finger
Zinc finger MYND domain-containing protein 19
HNH endonuclease

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYND19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYND19 as an antibody target. Whether an autoantibody or antibody against ZMYND19 could matter depends on whether native ZMYND19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYND19 is annotated at the cell surface, where native ZMYND19 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZMYND19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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