KLF15
Krueppel-like factor 15
Also known as: KKLF, KLF15_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UIH9
- Gene
- KLF15
- Ensembl
- ENSG00000163884
- Chromosome
- 3
- Canonical length
- 416 aa
- Protein class
- Disease related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear speckles,Vesicles
OverviewNCBI Gene
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
416 residues, UniProt reviewed canonical sequence.
>Q9UIH9|KLF15
1 MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL
61 CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF
121 CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS
181 HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG
241 QAPENVKVAQ LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP
301 AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP FACTWPGCGW
361 RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI KVHRFPRSSR SVRSVNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KLF15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 89 nTPM
Expression across tissuesHPA
Tissue
- liver: 89 nTPM
- skeletal muscle: 65 nTPM
- blood vessel: 56 nTPM
- pancreas: 47 nTPM
- ovary: 45 nTPM
- adipose tissue: 34 nTPM
Single-cell type
- breast lactating cells: 89 nCPM
- hepatocytes: 71 nCPM
- thymic myoid cells: 65 nCPM
- proximal tubule cells: 57 nCPM
- bergmann glia: 52 nCPM
- schwann cells: 36 nCPM
Immune cell
- basophil: 26 nTPM
- neutrophil: 17 nTPM
- NK-cell: 13 nTPM
- memory B-cell: 13 nTPM
- total PBMC: 12 nTPM
- naive B-cell: 12 nTPM
Brain region
- cerebral cortex: 140 nTPM
- medulla oblongata: 85 nTPM
- basal ganglia: 53 nTPM
- pons: 47 nTPM
- white matter: 47 nTPM
- midbrain: 44 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.61
- gnomAD pLI
- 0.49
- gnomAD missense Z
- 0.98
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cardiac muscle hypertrophy in response to stress
- cellular response to endothelin
- glial cell differentiation
- intracellular glucose homeostasis
- negative regulation of collagen biosynthetic process
- negative regulation of peptidyl-lysine acetylation
- negative regulation of transforming growth factor beta production
- podocyte differentiation
- positive regulation of D-glucose import
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- regulation of Wnt signaling pathway
- response to insulin
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of KLF15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KLF15 as an antibody target. Whether an autoantibody or antibody against KLF15 could matter depends on whether native KLF15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KLF15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KLF15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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