Seroatlas · Human Serome Atlas

MEOX2

Homeobox protein MOX-2

Also known as: GAX, MEOX2_HUMAN, MOX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50222
Gene: MEOX2
Ensembl: ENSG00000106511
Chromosome: 7
Canonical length: 304 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>P50222|MEOX2
     1  MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF
    61  ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP PSAARHSLCL QPDSGGPPEL
   121  GSSPPVLCSN SSSLGSSTPT GAACAPGDYG RQALSPAEAE KRSGGKRKSD SSDSQEGNYK
   181  SEVNSKPRKE RTAFTKEQIR ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM
   241  KWKRVKGGQQ GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE
   301  HAHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEOX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

placenta: 40 nTPM
adipose tissue: 38 nTPM
blood vessel: 31 nTPM
breast: 26 nTPM
lung: 13 nTPM
tongue: 12 nTPM

Single-cell type

fibro-adipogenic progenitors: 330 nCPM
mesothelial cells: 171 nCPM
vascular endothelial cells: 149 nCPM
leydig cells: 121 nCPM
vascular smooth muscle cells: 100 nCPM
pericytes: 100 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 5 nTPM
pons: 2.4 nTPM
thalamus: 2.4 nTPM
midbrain: 2.3 nTPM
cerebral cortex: 1.8 nTPM
hypothalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.91
gnomAD missense Z: -0.22
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEOX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEOX2 as an antibody target. Whether an autoantibody or antibody against MEOX2 could matter depends on whether native MEOX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEOX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEOX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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