Seroatlas · Human Serome Atlas

UBXN11

UBX domain-containing protein 11

Also known as: SOC, SOCI, UBX11_HUMAN, UBXD5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T124
Gene: UBXN11
Ensembl: ENSG00000158062
Chromosome: 1
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q5T124|UBXN11
     1  MSSPLASLSK TRKVPLPSEP MNPGRRGIRI YGDEDEVDML SDGCGSEEKI SVPSCYGGIG
    61  APVSRQVPAS HDSELMAFMT RKLWDLEQQV KAQTDEILSK DQKIAALEDL VQTLRPHPAE
   121  ATLQRQEELE TMCVQLQRQV REMERFLSDY GLQWVGEPMD QEDSESKTVS EHGERDWMTA
   181  KKFWKPGDSL APPEVDFDRL LASLQDLSEL VVEGDTQVTP VPGGARLRTL EPIPLKLYRN
   241  GIMMFDGPFQ PFYDPSTQRC LRDILDGFFP SELQRLYPNG VPFKVSDLRN QVYLEDGLDP
   301  FPGEGRVVGR QLMHKALDRV EEHPGSRMTA EKFLNRLPKF VIRQGEVIDI RGPIRDTLQN
   361  CCPLPARIQE IVVETPTLAA ERERSQESPN TPAPPLSMLR IKSENGEQAF LLMMQPDNTI
   421  GDVRALLAQA RVMDASAFEI FSTFPPTLYQ DDTLTLQAAG LVPKAALLLR ARRAPKSSLK
   481  FSPGPCPGPG PGPSPGPGPG PSPGPGPGPS PCPGPSPSPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 58 nTPM
basal ganglia: 48 nTPM
testis: 46 nTPM
cerebral cortex: 35 nTPM
hippocampal formation: 34 nTPM
amygdala: 31 nTPM

Single-cell type

late spermatids: 543 nCPM
oocytes: 502 nCPM
epididymal principal cells: 207 nCPM
respiratory ciliated cells: 173 nCPM
fallopian tube ciliated cells: 162 nCPM
epididymal efferent duct ciliated cells: 157 nCPM

Immune cell

classical monocyte: 94 nTPM
intermediate monocyte: 83 nTPM
non-classical monocyte: 74 nTPM
myeloid DC: 49 nTPM
total PBMC: 42 nTPM
naive B-cell: 17 nTPM

Brain region

choroid plexus: 73 nTPM
midbrain: 39 nTPM
hippocampal formation: 35 nTPM
medulla oblongata: 34 nTPM
basal ganglia: 32 nTPM
hypothalamus: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBXN11.

Disease | ImmuneIEDB

Conditions an epitope on UBXN11 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN11 as an antibody target. Whether an autoantibody or antibody against UBXN11 could matter depends on whether native UBXN11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...