Seroatlas · Human Serome Atlas

IKZF3

Zinc finger protein Aiolos

Also known as: Aiolos, IKZF3_HUMAN, ZNFN1A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKT9
Gene
IKZF3
Ensembl
ENSG00000161405
Chromosome
17
Canonical length
509 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>Q9UKT9|IKZF3
     1  MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV
    61  KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC
   121  DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN
   181  YACQRRDALT GHLRTHSVEK PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE
   241  ARHIKAEMGS ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ
   301  TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE MSNGAPQELE
   361  KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI YQQNHMVLSR ARNGMPLLKE
   421  VPRSYELLKP PPICPRDSVK VINKEGEVMD VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF
   481  ECNMCGYRSH DRYEFSSHIA RGEHRALLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IKZF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 38 nTPM
  • lymph node: 34 nTPM
  • thymus: 21 nTPM
  • spleen: 21 nTPM
  • appendix: 18 nTPM
  • small intestine: 11 nTPM

Single-cell type

  • b-cells: 402 nCPM
  • t-cells: 314 nCPM
  • nk-cells: 310 nCPM
  • plasma cells: 207 nCPM
  • mast cells: 165 nCPM
  • urothelial cells: 39 nCPM

Immune cell

  • MAIT T-cell: 29 nTPM
  • gdT-cell: 26 nTPM
  • memory CD8 T-cell: 20 nTPM
  • T-reg: 19 nTPM
  • memory B-cell: 13 nTPM
  • naive CD8 T-cell: 12 nTPM

Brain region

  • white matter: 5.5 nTPM
  • hippocampal formation: 5.2 nTPM
  • choroid plexus: 5 nTPM
  • cerebellum: 4.9 nTPM
  • medulla oblongata: 4.9 nTPM
  • cerebral cortex: 4.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IKZF3.

Disease | AllUniProt

Conditions IKZF3 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 80 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 84

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
2.14
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IKZF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IKZF3 as an antibody target. Whether an autoantibody or antibody against IKZF3 could matter depends on whether native IKZF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IKZF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IKZF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IKZF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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