Seroatlas · Human Serome Atlas

DDIT4L

DNA damage-inducible transcript 4-like protein

Also known as: DDT4L_HUMAN, REDD2, Rtp801L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96D03
Gene: DDIT4L
Ensembl: ENSG00000145358
Chromosome: 4
Canonical length: 193 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Actin filaments

OverviewNCBI Gene

Predicted to be involved in negative regulation of signal transduction. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q96D03|DDIT4L
     1  MVATGSLSSK NPASISELLD CGYHPESLLS DFDYWDYVVP EPNLNEVIFE ESTCQNLVKM
    61  LENCLSKSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP CGLRGCVMHV NLEIENVCKK
   121  LDRIVCDSSV VPTFELTLVF KQENCSWTSF RDFFFSRGRF SSGFRRTLIL SSGFRLVKKK
   181  LYSLIGTTVI EGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDIT4L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 303 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 303 nTPM
tongue: 100 nTPM
kidney: 23 nTPM
cervix: 22 nTPM
salivary gland: 16 nTPM
basal ganglia: 16 nTPM

Single-cell type

thymic myoid cells: 97 nCPM
conjunctival goblet cells: 77 nCPM
myonuclei: 54 nCPM
salivary duct cells: 29 nCPM
hofbauer cells: 27 nCPM
extravillous trophoblasts: 26 nCPM

Immune cell

memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

basal ganglia: 33 nTPM
medulla oblongata: 14 nTPM
pons: 13 nTPM
hippocampal formation: 11 nTPM
spinal cord: 9 nTPM
midbrain: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of signal transduction

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of DDIT4L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRKAB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDIT4L as an antibody target. Whether an autoantibody or antibody against DDIT4L could matter depends on whether native DDIT4L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDIT4L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDIT4L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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