Seroatlas · Human Serome Atlas

GET4

Golgi to ER traffic protein 4 homolog

Also known as: C7orf20, CEE, CGI-20, GET4_HUMAN, H_NH1244M04.5, TRC35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L5D6
Gene: GET4
Ensembl: ENSG00000239857
Chromosome: 7
Canonical length: 327 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitotic chromosome,Cytosol

OverviewNCBI Gene

Enables protein carrier chaperone and protein-folding chaperone binding activity. Involved in establishment of protein localization to membrane; maintenance of unfolded protein; and proteolysis involved in protein catabolic process. Located in chromosome; cytosol; and nuclear lumen. Part of BAT3 complex. Implicated in congenital disorder of glycosylation type IIy. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q7L5D6|GET4
     1  MAAAAAMAEQ ESARNGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQSKHT
    61  EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVEV ADELLENLAK VFSLMDPNSP
   121  ERVTFVSRAL KWSSGGSGKL GHPRLHQLLA LTLWKEQNYC ESRYHFLHSA DGEGCANMLV
   181  EYSTSRGFRS EVDMFVAQAV LQFLCLKNKS SASVVFTTYT QKHPSIEDGP PFVEPLLNFI
   241  WFLLLAVDGG KLTVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN
   301  LLTSLMGSSE QEDGEESPSD GSPIELD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GET4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 98 nTPM
liver: 97 nTPM
testis: 77 nTPM
kidney: 70 nTPM
pituitary gland: 69 nTPM
skeletal muscle: 54 nTPM

Single-cell type

oligodendrocytes: 27 nCPM
astrocytes: 25 nCPM
bergmann glia: 19 nCPM
other brain neurons: 18 nCPM
microglia: 16 nCPM
brain excitatory neurons: 15 nCPM

Immune cell

non-classical monocyte: 36 nTPM
plasmacytoid DC: 33 nTPM
eosinophil: 32 nTPM
myeloid DC: 29 nTPM
classical monocyte: 29 nTPM
NK-cell: 28 nTPM

Brain region

white matter: 77 nTPM
medulla oblongata: 61 nTPM
pons: 60 nTPM
cerebral cortex: 57 nTPM
thalamus: 56 nTPM
basal ganglia: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GET4.

Disease | AllUniProt

Conditions GET4 is implicated in, by any mechanism.

Congenital disorder of glycosylation 2Y (CDG2Y) MIM:620200

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.56
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Golgi to ER traffic protein 4
Golgi to ER traffic protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GET4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GET4 as an antibody target. Whether an autoantibody or antibody against GET4 could matter depends on whether native GET4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GET4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GET4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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