Seroatlas · Human Serome Atlas

STX11

Syntaxin-11

Also known as: STX11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75558
Gene
STX11
Ensembl
ENSG00000135604
Chromosome
6
Canonical length
287 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>O75558|STX11
     1  MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD IQDENQLLVA
    61  DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI HCKLRAMKEL SEAAEAQHGP
   121  HSAVARISRA QYNALTLTFQ RAMHDYNQAE MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM
   181  FEQGKWDVFS ENLLADVKGA RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD
   241  TLNVIELNVQ KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
141 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 141 nTPM
  • adipose tissue: 26 nTPM
  • lung: 19 nTPM
  • spleen: 16 nTPM
  • appendix: 11 nTPM
  • lymph node: 9.3 nTPM

Single-cell type

  • neutrophils: 919 nCPM
  • monocytes: 490 nCPM
  • neutrophil progenitors: 391 nCPM
  • monocyte progenitors: 357 nCPM
  • cdc: 271 nCPM
  • megakaryocytes: 266 nCPM

Immune cell

  • neutrophil: 205 nTPM
  • non-classical monocyte: 200 nTPM
  • intermediate monocyte: 182 nTPM
  • classical monocyte: 162 nTPM
  • total PBMC: 110 nTPM
  • eosinophil: 103 nTPM

Brain region

  • cerebral cortex: 6.3 nTPM
  • white matter: 5.2 nTPM
  • thalamus: 4.9 nTPM
  • medulla oblongata: 4.7 nTPM
  • pons: 4.4 nTPM
  • spinal cord: 4.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX11.

Disease | AllUniProt

Conditions STX11 is implicated in, by any mechanism.

  • Hemophagocytic lymphohistiocytosis, familial, 4 (FHL4) MIM:603552

Disease | GeneticClinVar

32 pathogenic / likely-pathogenic of 420 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX11 as an antibody target. Whether an autoantibody or antibody against STX11 could matter depends on whether native STX11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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